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12 July 2020: Database Analysis

Clinical Features and Prognosis of Merkel Cell Carcinoma in Elderly Patients

YiJun Xia 1ABE , DongSheng Cao 1BD , Jun Zhao 2C , BangZhong Zhu 1D , Juan Xie 1ADEF*

DOI: 10.12659/MSM.924570

Med Sci Monit 2020; 26:e924570

Table 3 Univariate and multivariate survival analysis of elderly patients with Merkel cell carcinoma.

VariablesOverall survivalMCC-specific Survival
UnivariableMultivariableUnivariableMultivariable
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Age
 65–80ReferenceReferenceReferenceReference
 >802.096 (1.845–2.381)1.714 (1.489–1.973)1.219 (0.970–1.531)0.0891.009 (0.782–1.302)0.945
Race
 WhiteReferenceReferenceReferenceReference
 Black0.856 (0.543–1.348)0.5020.760 (0.479–1.205)0.2431.118 (0.554–2.256)0.7561.157 (0.561–2.388)0.693
 Other0.208 (0.029–1.479)0.1170.195 (0.027–1.396)0.1040.9370.808
 Unknown
Sex
 MaleReferenceReferenceReference
 Female0.713 (0.622–0.818)0.660 (0.567–0.768)0.702 (0.548–0.899)0.0050.786 (0.597–1.034)0.086
Marital status
 SingleReferenceReferenceReferenceReference
 Married0.840 (0.646–1.092)0.1930.906 (0.693–1.183)0.4680.649 (0.379–1.113)0.1160.739 (0.424–1.288)0.286
 Unknown
Primary site
 Face/head/neckReferenceReferenceReferenceReference
 Trunk0.727 (0.632–0.836)0.847 (0.728–0.986)0.0320.742 (0.574–0.960)0.0230.770 (0.580–1.022)0.070
 Upper and lower extremities1.049 (0.777–1.416)0.7560.832 (0.438–1.580)0.5741.893 (1.235–2.901)0.0031.368 (0.488–3.833)0.551
 Other
Tumor size
 No mass/tumor foundReferenceReferenceReferenceReference
 1–10 mm0.553 (0.402–0.761)0.400 (0.164–0.976)0.0440.277 (0.170–0.453)0.624 (0.086–4.556)0.642
 11–20 mm0.803 (0.588–1.097)0.1680.557 (0.229–1.355)0.1970.452 (0.284–0.719)0.0010.959 (0.132–6.943)0.967
 21–30 mm1.067 (0.772–1.475)0.6930.559 (0.187–1.677)0.3000.610 (0.373–0.998)0.0491.133 (0.107–11.949)0.918
 31–40 mm1.189 (0.833–1.696)0.3410.535 (0.176–1.628)0.2710.820 (0.478–1.406)0.4701.303 (0.121–13.989)0.827
 41–50 mm1.198 (0.814–1.765)0.3600.559 (0.182–1.719)0.3100.877 (0.485–1.585)0.6641.639 (0.151–17.830)0.685
 >50 mm1.692 (1.185–2.415)0.0040.705 (0.225–2.213)0.5501.535 (0.921–2.558)0.1001.786 (0.160–19.936)0.637
 Unknown1.796 (0.930–3.467)0.0810.577 (0.173–1.929)0.3721.306 (0.452–3.778)0.6220.944 (0.077–11.634)0.964
T stage
 T0ReferenceReferenceReferenceReference
 T10.691 (0.502–0.951)0.0232.236 (0.722–6.929)0.1630.347 (0.221–0.546)1.778 (0.185–17.069)0.618
 T21.126 (0.813–1.561)0.4742.622 (0.723–9.510)0.1430.650 (0.409–1.035)0.0701.351 (0.102–17.876)0.820
 T31.604 (1.092–2.355)0.0162.484 (0.648–9.524)0.1851.421 (0.831–2.429)0.1992.099 (0.148–29.773)0.584
 T41.576 (1.070–2.323)0.0212.628 (0.763–9.045)0.1261.038 (0.582–1.852)0.8981.555 (0.125–19.390)0.732
 Unknown
N stage
 N0ReferenceReferenceReferenceReference
 N11.823 (1.598–2.079)2.178 (1.654–2.869)3.567 (2.813–4.524)4.335 (2.812–6.684)
 N22.251 (1.632–3.104)1.804 (1.231–2.643)0.0025.365 (3.371–8.539)4.500 (2.553–7.931)
 Unknown
M stage
 M0ReferenceReferenceReferenceReference
 M14.397 (3.569–5.415)1.967 (1.458–2.653)8.056 (5.979–10.854)2.951 (1.915–4.548)
Primary site surgery
 NoReferenceReferenceReferenceReference
 Yes0.535 (0.448–0.640)0.917 (0.720–1.169)0.4850.437 (0.325–0.588)1.128 (0.720–1.767)0.600
 Unknown1.634 (0.229–11.684)0.6251.683 (0.188–15.043)0.6420.9360.930
Scope regional lymph node surgery
 NoneReferenceReferenceReferenceReference
 Regional lymph nodes removed0.904 (0.778–1.050)0.1870.449 (0.209–0.964)0.0401.418 (1.094–1.838)0.0080.138 (0.027–0.699)0.017
 Sentinel lymph node biopsy0.382 (0.320–0.456)0.327 (0.151–0.712)0.0050.412 (0.293–0.580)0.089 (0.017–0.461)0.004
 Sentinel lymph node biopsy+regional lymph nodes removed0.607 (0.465–0.794)0.343 (0.154–0.765)0.0090.814 (0.512–1.294)0.3840.090 (0.017–0.484)0.005
 Unknown1.195 (0.657–2.174)0.5590.894 (0.464–1.720)0.7362.048 (0.837–5.011)0.1171.265 (0.429–3.727)0.670
Regional nodes examined
 NoReferenceReferenceReferenceReference
 Yes0.619 (0.545–0.702)1.479 (0.682–3.209)0.3220.963 (0.686–1.087)0.2115.510 (0.952–28.868)0.073
 Unknown2.127 (0.530–8.536)0.2870.9063.791 (0.529–27.160)0.1850.888
Regional nodes positive
 NoReferenceReferenceReferenceReference
 Yes2.789 (2.317–3.358)0.961 (0.690–1.339)0.8154.662 (3.285–6.615)0.723 (0.414–1.262)0.253
 No nodes examined2.797 (2.346–3.334)0.9252.930 (2.056–4.176)
 Unknown2.371 (0.588–9.562)0.2250.9065.152 (0.708–37.493)0.1050.893
Radiation
 NoReferenceReferenceReferenceReference
 Yes0.727 (0.640–0.825)0.725 (0.630–0.834)1.025 (0.817–1.285)0.8330.943 (0.732–1.215)0.650
Chemotherapy
 No/unknownReferenceReferenceReferenceReference
 Yes1.929 (1.609–2.312)1.178 (0.936–1.482)0.1643.273 (2.493–4.298)1.072 (0.755–1.522)0.697
Bone metastasis
 NoReferenceReferenceReferenceReference
 Yes4.505 (2.945–6.893)0.822 (0.478–1.414)0.4799.004 (5.239–15.477)1.082 (0.530–2.208)0.829
 Unknown3.667 (2.075–6.483)0.309 (0.017–5.632)0.4285.123 (2.115–12.411)0.950
Brain metastasis
 NoReferenceReferenceReferenceReference
 Yes10.389 (2.585–41.749)0.0014.384 (0.956–20.113)0.05734.582 (8.510–140.539)4.062 (0.717–23.013)0.113
 Unknown3.594 (2.079–6.214)4.322 (0.582–32.101)0.1534.482 (1.851–10.854)0.0010.948
Liver metastasis
 NoReferenceReferenceReferenceReference
 Yes7.016 (4.905–10.034)1.883 (1.176–3.015)0.00814.114 (8.867–22.466)2.790 (1.476–5.274)0.002
 Unknown3.716 (2.102–6.569)5.257 (2.170–12.737)
Lung metastasis
 NoReferenceReferenceReferenceReference
 Yes3.866 (2.422–6.172)0.913 (0.524–1.592)0.7486.179 (3.174–12.028)0.843 (0.369–1.925)0.685
 Unknown3.858 (2.231–6.671)1.448 (0.188–11.169)0.7225.094 (2.629–13.261)3.937 (0.455–34.061)0.213
HR – hazard ratio; CI – confidence interval.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750