Association Between Ghrelin Gene Polymorphism and Cerebral Infarction

15 July 2020: Clinical Research

Li Chen ^1ABE , Hua Zhao ^1BCF , Jing Shen ^2DF , Xiaoyu Ji ^3ACG*

DOI: 10.12659/MSM.924539

Med Sci Monit 2020; 26:e924539

Table 3 Analysis of polymorphisms at ghrelin gene loci rs26312, rs26802, and rs27647.

	Locus	Genotype	Control group	Disease group	χ2	P
Dominant model	rs26312	GG+GA	162 (0.810)	151 (0.755)	2.81	0.381
	rs26312	AA	38 (0.190)	49 (0.245)	2.81	0.381
	rs26802	TT+TG	152 (0.760)	140 (0.700)	1.51	0.583
	rs26802	GG	48 (0.240)	60 (0.300)	1.51	0.583
	rs27647	CC+CT	155 (0.775)	171 (0.855)	7.45	0.023
	rs27647	TT	45 (0.225)	29 (0.145)	7.45	0.023
Recessive model	rs26312	GG	49 (0.245)	42 (0.210)	2.14	0.401
	rs26312	GA+AA	151 (0.755)	158 (0.790)	2.14	0.401
	rs26802	TT	61 (0.305)	38 (0.190)	6.34	0.033
	rs26802	TG+GG	139 (0.695)	162 (0.810)	6.34	0.033
	rs27647	CC	50 (0.250)	35 (0.175)	2.34	0.451
	rs27647	CT+TT	150 (0.750)	165 (0.825)	2.34	0.451
Heterozygous model	rs26312	GG	49 (0.245)	42 (0.210)	1.93	0.485
	rs26312	GA	113 (0.565)	109 (0.545)	1.93	0.485
	rs26802	TT	61 (0.305)	38 (0.190)	3.95	0.058
	rs26802	TG	91 (0.455)	102 (0.510)	3.95	0.058
	rs27647	CC	50 (0.250)	35 (0.175)	8.34	0.007
	rs27647	CT	105 (0.525)	136 (0.680)	8.34	0.007
Homozygous model	rs26312	GG	49 (0.245)	42 (0.210)	2.74	0.331
	rs26312	AA	38 (0.190)	49 (0.245)	2.74	0.331
	rs26802	TT	61 (0.305)	38 (0.190)	2.38	0.351
	rs26802	GG	48 (0.240)	60 (0.300)	2.38	0.351
	rs27647	CC	50 (0.250)	35 (0.175)	3.01	0.134
	rs27647	TT	45 (0.225)	29 (0.145)	3.01	0.134