17 August 2020: Clinical Research
Evaluation of Ovarian Tumors with Multidetector Computed Tomography and Tumor Markers: Differentiation of Stage I Serous Borderline Tumors and Stage I Serous Malignant Tumors Presenting as Solid-Cystic Mass
Xin-Ping Yu 1BCE , Ying Liu 2C , Jin-Wen Jiao 1D , Hong-Juan Yang 1B , Rui-Jing Wang 1D , Shuai Zhang 3ACF*DOI: 10.12659/MSM.924497
Med Sci Monit 2020; 26:e924497
Table 5 Diagnostic performance of tumor markers and MDCT parameter for predicting SMOTs by ROC analyses.
| Parameter | AUC | Sensitivity (%) | Specificity (%) | Threshold value |
|---|---|---|---|---|
| Age (years) | 0.750 | 70.4 | 75.0 | 46.5 |
| CA125 (U/mL) | 0.662 | 42.6 | 89.6 | 457.5 |
| HE4 (pmol/L) | 0.726 | 57.4 | 83.3 | 107.0 |
| Maximum thickness of wall (mm) | 0.688 | 81.5 | 50.0 | 2.55 |
| Maximum thickness of septa (mm) | 0.674 | 74.1 | 62.5 | 3.1 |
| Maximum diameter of solid component (mm) | 0.781 | 68.5 | 77.1 | 40.3 |
| Combination of age, vascular abnormalities and maximum diameter of solid portion | 0.939 | 88.9 | 85.4 | – |
| MDCT – multidetector computed tomography; SMOTs – serous malignant ovarian tumors; ROC – receiver operating characteristics; AUC – area under the ROC curve; CA125 – serum cancer antigen 125; HE4 – human epididymis protein 4. | ||||