01 August 2020: Clinical Research
Effects of Occupational Stress and Circadian CLOCK Gene Polymorphism on Sleep Quality of Oil Workers in Xinjiang, China
Li Ning 1BCDEF* , Lingyun Shi 2BCDEF* , Ning Tao 1BC , Rong Li 1BC , Ting Jiang 1BC , Jiwen Liu 1ABEG*DOI: 10.12659/MSM.924202
Med Sci Monit 2020; 26:e924202
Table 13 The risk analysis of CLOCK, Per2, and Per3 genotypes in sleep disorder.
| Gene | Genotype/allele type | OR (95% CI) | OR# (95% CI) |
|---|---|---|---|
| CLOCK | rs1801260 | ||
| TT | 1 | 1 | |
| TC | 0.431 (0.263–0.704)** | 0.412 (0.245–0.695)** | |
| CC | 0.583 (0.220–1.545) | 0.445 (0.158–1.257) | |
| CLOCK | rs6850524 | ||
| GG | 1 | 1 | |
| GC | 0.515 (0.320–0.828)** | 0.357 (0.245–0.695)** | |
| CC | 0.610 (0.270–1.380) | 0.317 (0.128–0.785)* | |
| Per2 | rs2304672 | ||
| CC | 1 | 1 | |
| CG | 0.702 (0.375–1.314) | 0.617 (0.317–1.202) | |
| GG | 0 | 0 | |
| Per3 | 4/4 | 1 | 1 |
| 4/5 | 1.902 (1.056–3.424)* | 1.691 (0.912–3.135) | |
| 5/5 | 2.712 (0.685–10.737) | 1.676 (0.392–7.155) | |
| OR – after adjusting individual stress and occupational stress levels. * 0.05, ** 0.01. | |||