01 August 2020: Clinical Research
Effects of Occupational Stress and Circadian CLOCK Gene Polymorphism on Sleep Quality of Oil Workers in Xinjiang, China
Li Ning 1BCDEF* , Lingyun Shi 2BCDEF* , Ning Tao 1BC , Rong Li 1BC , Ting Jiang 1BC , Jiwen Liu 1ABEG*DOI: 10.12659/MSM.924202
Med Sci Monit 2020; 26:e924202
Table 12 The distribution of CLOCK, Per2, and Per3 genotypes and alleles among populations with different sleep states.
| Gene | Genotype/allele type | Sleep disorder-positive (%) | Sleep disorder-negative (%) | χ2 | P |
|---|---|---|---|---|---|
| CLOCK | TT | 107 (69.48) | 78 (50.65) | 11.711 | 0.003 |
| rs1801260 | TC | 39 (25.32) | 66 (42.86) | ||
| CC | 8 (5.19) | 10 (6.49) | |||
| T | 253 (82.14) | 222 (72.08) | 0.905 | ||
| C | 55 (17.86) | 86 (27.92) | |||
| CLOCK | GG | 81 (52.60) | 57 (37.01) | 7.725 | |
| rs6850524 | GC | 60 (38.96) | 82 (53.25) | ||
| CC | 13 (8.44) | 15 (9.74) | |||
| G | 222 (72.08) | 196 (63.64) | 5.031 | ||
| C | 86 (27.92) | 112 (36.36) | |||
| Per2 | CC | 134 (87.01) | 127 (82.47) | 1.230 | 0.267 |
| rs2304672 | CG | 20 (12.99) | 27 (17.53) | ||
| GG | 0 (0.00) | 0 (0.00) | |||
| C | 288 (93.51) | 281 (91.23) | 1.129 | 0.288 | |
| G | 20 (6.49) | 27 (8.77) | |||
| Per3 | 4/4 | 111 (72.08) | 129 (83.77) | 6.329 | |
| 4/5 | 36 (23.38) | 22 (14.29) | |||
| 5/5 | 7 (4.55) | 3 (1.95) | |||
| 4 | 258 (83.77) | 280 (90.91) | 7.105 | 0.008 | |
| 5 | 50 (16.23) | 28 (9.91) |