19 July 2020: Database Analysis
Systematic Profiling of Alternative Splicing for Sarcoma Patients Reveals Novel Prognostic Biomarkers Associated with Tumor Microenvironment and Immune Cells
Chuan Hu 1ABCEF , Yuanhe Wang 1ABC , Chuan Liu 2DEF , Rui Shen 1DE , Bo Chen 3F , Kang Sun 1B , Huili Rao 4C , Lin Ye 3E , Jianjun Ye 3C , Shaoqi Tian 1ABCDEF*DOI: 10.12659/MSM.924126
Med Sci Monit 2020; 26:e924126
Table 3 Univariate Cox analysis of clinicopathologic factors for sarcoma patients.
| Overall survival | Disease-free survival | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95.0% CI | P | HR | 95.0% CI | P | |||
| Risk classification based on AS events | ||||||||
| Low-risk | 0.000 | 0.000 | ||||||
| Mid-risk | 4.620 | 2.345 | 9.103 | 0.000 | 3.688 | 2.175 | 6.251 | 0.000 |
| High-risk | 26.918 | 12.932 | 56.027 | 0.000 | 14.003 | 7.559 | 25.943 | 0.000 |
| Age | ||||||||
| Low-age | 0.008 | 0.075 | ||||||
| Mid-age | 0.989 | 0.508 | 1.925 | 0.975 | 1.094 | 0.664 | 1.802 | 0.725 |
| High-age | 2.371 | 1.269 | 4.430 | 0.007 | 1.659 | 1.027 | 2.679 | 0.039 |
| Sex (Female) | 1.080 | 0.637 | 1.830 | 0.776 | 1.214 | 0.824 | 1.787 | 0.326 |
| Neoplasm histologic type name | ||||||||
| Dedifferentiated liposarcoma | 0.350 | 0.194 | ||||||
| Leiomyosarcoma | 0.617 | 0.331 | 1.153 | 0.130 | 0.665 | 0.417 | 1.059 | 0.086 |
| Undifferentiated pleomorphic sarcoma | 0.703 | 0.315 | 1.566 | 0.388 | 0.716 | 0.396 | 1.294 | 0.268 |
| Other | 0.510 | 0.213 | 1.224 | 0.132 | 0.531 | 0.277 | 1.017 | 0.056 |
| Disease multifocal indicator | 2.628 | 1.469 | 4.700 | 0.001 | 2.119 | 1.310 | 3.427 | 0.002 |
| Surgical margin resection status (rother) | 2.638 | 1.552 | 4.484 | 0.000 | 2.216 | 1.497 | 3.280 | 0.000 |
| Tumor tissue site | ||||||||
| Chest | 0.943 | 0.668 | ||||||
| Gynecological | 2.460 | 0.302 | 20.038 | 0.400 | 2.259 | 0.499 | 10.215 | 0.290 |
| Head and neck | 0.000 | 0.000 | 2.876E+250 | 0.972 | 3.171 | 0.443 | 22.695 | 0.251 |
| Lower abdominal/pelvic | 1.086 | 0.098 | 12.012 | 0.946 | 1.637 | 0.317 | 8.463 | 0.556 |
| Lower extremity | 1.958 | 0.260 | 14.740 | 0.514 | 1.852 | 0.442 | 7.759 | 0.399 |
| Retroperitoneum/upper abdominal | 2.220 | 0.301 | 16.388 | 0.434 | 2.130 | 0.516 | 8.789 | 0.296 |
| Superficial trunk | 1.799 | 0.163 | 19.909 | 0.632 | 0.878 | 0.123 | 6.265 | 0.897 |
| Upper extremity | 1.015 | 0.063 | 16.298 | 0.992 | 3.339 | 0.671 | 16.615 | 0.141 |
| AS – alternative splicing; HR – hazard ratio. | ||||||||