07 May 2020: Lab/In Vitro Research
Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis
Mingzhu Wang 1CDEF , Yanan Shi 1BDF , Lei Yao 1CDF , Qiang Li 2ACDFG , Youhua Wang 3ABDFG , Deyu Fu 1ABEFG*DOI: 10.12659/MSM.924092
Med Sci Monit 2020; 26:e924092
Table 5 Molecular docking results via Sybyl-X 2.0.
| Name | Total-Score | Crash | Polar | C-score |
|---|---|---|---|---|
| Trichostatin A | 4.6014 | −1.5507 | 3.383 | 4 |
| Heptaminol | 4.49 | −0.7964 | 3.4511 | 4 |
| Vorinostat | 3.9372 | −0.5783 | 2.9081 | 5 |
| Adiphenine | 3.3728 | −0.8786 | 0 | 5 |
| Tranexamic acid | 3.3326 | −0.1967 | 3.059 | 2 |
| Phenoxybenzamine | 2.9859 | −0.8832 | 0 | 3 |
| Parthenolide | 2.617 | −0.4027 | 0 | 5 |
| Thioridazine | 2.2178 | −0.9797 | 0 | 2 |
| Tanespimycin | 2.201 | −2.6622 | 2.8124 | 2 |
| LY-294002 | 1.5561 | −0.2973 | 0 | 2 |