07 May 2020: Lab/In Vitro Research
Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis
Mingzhu Wang 1CDEF , Yanan Shi 1BDF , Lei Yao 1CDF , Qiang Li 2ACDFG , Youhua Wang 3ABDFG , Deyu Fu 1ABEFG*DOI: 10.12659/MSM.924092
Med Sci Monit 2020; 26:e924092
Table 4 Top 10 most significant compounds based on CMAP for AC-induced cardiotoxicity.
| CMAP name | Mean | n | Enrichment | p | Specificity |
|---|---|---|---|---|---|
| Phenoxybenzamine | −0.834 | 4 | −0.982 | 0 | 0 |
| Parthenolide | −0.787 | 4 | −0.963 | 0 | 0 |
| Tanespimycin | −0.448 | 62 | −0.368 | 0 | 0.2185 |
| Trichostatin A | −0.385 | 182 | −0.318 | 0 | 0.505 |
| Thioridazine | −0.512 | 20 | −0.507 | 0.00002 | 0.1505 |
| Heptaminol | 0.665 | 5 | 0.919 | 0.00004 | 0 |
| Adiphenine | 0.679 | 5 | 0.867 | 0.00008 | 0.0053 |
| Tranexamic acid | 0.602 | 5 | 0.864 | 0.00008 | 0 |
| Vorinostat | −0.521 | 12 | −0.597 | 0.00018 | 0.2655 |
| LY-294002 | −0.283 | 61 | −0.268 | 0.0002 | 0.4233 |
| CMAP – connectivity map; AC – aconitine. | |||||