Potential Molecular Mechanisms and Drugs for Aconitine-Induced Cardiotoxicity in Zebrafish through RNA Sequencing and Bioinformatics Analysis

07 May 2020: Lab/In Vitro Research

Mingzhu Wang ^1CDEF , Yanan Shi ^1BDF , Lei Yao ^1CDF , Qiang Li ^2ACDFG , Youhua Wang ^3ABDFG , Deyu Fu ^1ABEFG*

DOI: 10.12659/MSM.924092

Med Sci Monit 2020; 26:e924092

Table 2 Topological parameters of the targets.

Gene symbol	DC	BC	Closeness
CDK1	192	148	0.92
PLK1	154	73	0.89
AURKB	147	69	0.90
PCNA	147	51	0.84
CCNA2	132	66	0.88
TOP2A	128	53	0.83
FEN1	126	58	0.84
TYMS	123	52	0.86
POLA1	121	55	0.86
RRM1	119	23	0.87
BC – betweenness centrality; DC – degree centrality. The topological properties were calculated though CytoNCA.