05 August 2020: Database Analysis
Integrated Analysis of Hub Genes and Pathways In Esophageal Carcinoma Based on NCBI’s Gene Expression Omnibus (GEO) Database: A Bioinformatics Analysis
Tan Yu-jing ACE , Tang Wen-jing C , Tang Biao AEG*DOI: 10.12659/MSM.923934
Med Sci Monit 2020; 26:e923934
Table 3 KEGG pathway enrichment analysis of ESCA-related DEGs.
| Term | Number | Corrected p value | Genes |
|---|---|---|---|
| Cell cycle | 10 | 1.19E-08 | CCNB2, CCNB1, CCNA2, BUB1B, CCNE2, CDC20, TTK, MCM4, MCM2, BUB1 |
| cGMP-PKG signaling pathway | 9 | 1.51E-06 | MRVI1, MYLK, KCNMA1, ADRB1, ATP1A2, RGS2, PLN, AGTR1, MYL9 |
| Vascular smooth muscle contraction | 8 | 2.68E-06 | MYH11, MRVI1, AVPR1A, ACTG2, MYLK, KCNMA1, AGTR1, MYL9 |
| AGE-RAGE signaling pathway in diabetic complications | 6 | 0.000105714 | CCL2, IL6, COL1A2, COL1A1, COL3A1, AGTR1 |
| Pathways in cancer | 11 | 0.00016471 | CXCL12, CCNE2, BIRC5, KIT, IL6, HLF, FGF7, LPAR3, AGTR1, HEY1, MMP1 |
| PI3K-Akt signaling pathway | 9 | 0.000181898 | GHR, CCNE2, KIT, IL6, COL1A2, EREG, COL1A1, FGF7, LPAR3 |
| Platelet activation | 6 | 0.000181898 | PTGS1, MYLK, RAP1A, COL1A2, COL1A1, COL3A1 |
| Calcium signaling pathway | 7 | 0.000181898 | AVPR1A, CASQ2, MYLK, ADRB1, PLN, AGTR1, CYSLTR1 |
| Oocyte meiosis | 6 | 0.000181898 | CCNB2, CCNB1, BUB1, CCNE2, CDC20, AURKA |
| Cytokine-cytokine receptor interaction | 8 | 0.000256568 | CCL2, IL1RN, TNFSF10, GHR, DTL, IL6, IL36A, CXCL12 |
| Protein digestion and absorption | 5 | 0.000372719 | COL3A1, COL14A1, COL1A2, ATP1A2, COL1A1 |
| Rheumatoid arthritis | 5 | 0.000372719 | IL6, CCL2, CXCL12, DTL, MMP1 |
| Progesterone-mediated oocyte maturation | 5 | 0.000505745 | CCNB2, CCNB1, CCNA2, AURKA, BUB1 |
| p53 signaling pathway | 4 | 0.001955985 | CCNE2, CCNB2, CCNB1, GTSE1 |
| Human T-cell leukemia virus 1 infection | 6 | 0.001955985 | CCNB2, CCNA2, BUB1B, CCNE2, CDC20, IL6 |
| Adrenergic signaling in cardiomyocytes | 5 | 0.002613273 | ADRB1, AGTR1, SCN7A, ATP1A2, PLN |
| Neuroactive ligand-receptor interaction | 7 | 0.002678945 | AVPR1A, GHR, P2RY14, ADRB1, LPAR3, AGTR1, CYSLTR1 |
| ECM-receptor interaction | 4 | 0.003021888 | HMMR, COL1A2, CD36, COL1A1 |
| Cellular senescence | 5 | 0.003023275 | IL6, CCNB2, CCNB1, CCNE2, CCNA2 |
| Jak-STAT signaling pathway | 5 | 0.003030745 | IL6, AOX1, FHL1, GHR, SOCS2 |
| Tyrosine metabolism | 3 | 0.003030745 | AOX1, AOC3, ADH1B |
| Amoebiasis | 4 | 0.003552075 | IL6, COL3A1, COL1A2, COL1A1 |
| Viral protein interaction with cytokine and cytokine receptor | 4 | 0.004092655 | IL6, CCL2, CXCL12, TNFSF10 |
| Malaria | 3 | 0.005771037 | IL6, CCL2, CD36 |
| Intestinal immune network for IgA production | 3 | 0.005771037 | IL6, CXCL12, DTL |
| Focal adhesion | 5 | 0.005771037 | MYL9, COL1A2, MYLK, RAP1A, COL1A1 |
| cAMP signaling pathway | 5 | 0.007342941 | ADRB1, MYL9, ATP1A2, RAP1A, PLN |
| Regulation of actin cytoskeleton | 5 | 0.007342941 | FGF7, CFD, CXCL12, MYLK, MYL9 |
| Relaxin signaling pathway | 4 | 0.008337936 | COL3A1, COL1A1, COL1A2, MMP1 |
| FoxO signaling pathway | 4 | 0.008510363 | IL6, CCNB2, CCNB1, TNFSF10 |
| Renin secretion | 3 | 0.011964411 | ADRB1, AGTR1, KCNMA1 |
| Phospholipase D signaling pathway | 4 | 0.011964411 | LPAR3, AGTR1, AVPR1A, KIT |
| PPAR signaling pathway | 3 | 0.015020846 | SORBS1, CD36, MMP1 |
| Hepatitis B | 4 | 0.015736213 | IL6, CCNE2, BIRC5, CCNA2 |
| Complement and coagulation cascades | 3 | 0.015736213 | CLU, C7, CFH |
| Tight junction | 4 | 0.017269759 | MYH11, EPB41L4B, RAP1A, MYL9 |
| Salivary secretion | 3 | 0.021192296 | ADRB1, KCNMA1, ATP1A2 |
| MicroRNAs in cancer | 5 | 0.021964309 | DNMT3B, CCNE2, EZH2, KIF23, SOX4 |
| IL-17 signaling pathway | 3 | 0.021964309 | IL6, CCL2, MMP1 |
| Hematopoietic cell lineage | 3 | 0.023983878 | IL6, CD36, KIT |
| Pancreatic secretion | 3 | 0.024052267 | KCNMA1, RAP1A, ATP1A2 |
| Human papillomavirus infection | 5 | 0.029816413 | CCNE2, CCNA2, COL1A1, COL1A2, HEY1 |
| Rap1 signaling pathway | 4 | 0.029816413 | FGF7, LPAR3, RAP1A, KIT |
| Prion diseases | 2 | 0.030030738 | IL6, C7 |
| DNA replication | 2 | 0.03062247 | MCM4, MCM2 |
| Leukocyte transendothelial migration | 3 | 0.03062247 | CXCL12, RAP1A, MYL9 |
| AMPK signaling pathway | 3 | 0.035976653 | CAB39L, CCNA2, CD36 |