19 August 2020: Database Analysis
A Predictive Nomogram for Early Mortality in Stage IV Gastric Cancer
Yuqian Feng 1ACDE* , Kaibo Guo 1ABDE* , Huimin Jin 1BC , Yuying Xiang 1D , Yiting Zhang 1E , Shanming Ruan 2AFG*DOI: 10.12659/MSM.923931
Med Sci Monit 2020; 26:e923931
Supplementary Table 1 Multivariable Cox regression for analyzing the risk factors for early death.
| Factors | Total early death | Cancer-specific early death | Non-cancer-specific early death | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR(95% CI) | P-value | |
| ≤55 | Ref | 1 | Ref | 1 | Ref | 1 |
| 56–65 | 0.853 (0.481–1.513) | 0.587 | 0.917 (0.707–1.188) | 0.510 | 1.472 (0.877–2.472) | 0.144 |
| 66–75 | 2.625 (1.601–4.302) | 1.586 (1.210–2.079) | 3.138 (1.938–5.083) | |||
| ≥76 | 2.532 (1.534–4.179) | 1.461 (1.106–1.930) | 0.008 | 3.790 (2.328–6.172) | ||
| White | Ref | 1 | Ref | 1 | Ref | 1 |
| Black | 1.031 (0.644–1.652) | 0.898 | NS | NS | NS | NS |
| Asian or Pacific Islander | 0.627 (0.400–0.981) | 0.041 | NS | NS | NS | NS |
| American Indian/Alaska Native | 1.563 (0.314–7.778) | 0.585 | NS | NS | NS | NS |
| Unknown | NA | NA | NA | NA | NA | NA |
| Female | Ref | 1 | Ref | 1 | Ref | 1 |
| Male | NS | NS | NS | NS | NS | NS |
| Unmarried | Ref | 1 | Ref | 1 | Ref | 1 |
| Married | 0.750 (0.532–1.056) | 0.099 | 0.992 (0.814–1.209) | 0.934 | 0.808 (0.592–1.103) | 0.180 |
| Unknown | NA | NA | NA | NA | NA | NA |
| Uninsured | Ref | 1 | Ref | 1 | Ref | 1 |
| Insured | 1.710 (0.618–4.731) | 0.301 | 1.172 (0.769–1.786) | 0.460 | 1.575 (0.577–4.297) | 0.375 |
| Unknown | NA | NA | NA | NA | NA | NA |
| Non-cardia | Ref | 1 | Ref | 1 | Ref | 1 |
| Cardia | 0.336 (0.171–0.660) | 0.002 | 0.832 (0.623–1.113) | 0.215 | NS | NS |
| Unknown | NA | NA | NA | NA | NA | NA |
| Adenocarcinoma(exclude signet ring cell) | Ref | 1 | Ref | 1 | Ref | 1 |
| Signet ring cell | NS | NS | 0.968 (0.761–1.231) | 0.791 | 0.808 (0.538–1.213) | 0.304 |
| Others | NA | NA | NA | NA | NA | NA |
| Ref | 1 | Ref | 1 | Ref | 1 | |
| ≥3 | 0.998 (0.530–1.878) | 0.994 | 1.513 (1.046–2.191) | 0.028 | NS | NS |
| ≥5 | 0.745 (0.422–1.497) | 0.477 | 1.259 (0.873–1.815) | 0.218 | NS | NS |
| ≥7 | 1.093 (0.563–2.121) | 0.792 | 1.380 (0.932–2.042) | 0.108 | NS | NS |
| ≥9 | 1.020 (0.531–1.961) | 0.953 | 1.237 (0.831–1.843) | 0.295 | NS | NS |
| Unknown | NA | NA | NA | NA | NA | NA |
| T1 | Ref | 1 | Ref | 1 | Ref | 1 |
| T2 | 0.404 (0.107–1.524) | 0.181 | 0.842 (0.436–1.626) | 0.609 | 0.767 (0.408–1.442) | 0.410 |
| T3 | 0.876 (0.399–1.922) | 0.741 | 1.394 (0.843–2.306) | 0.195 | 0.735 (0.484–1.119) | 0.151 |
| T4 | 1.273 (0.590–2.750) | 0.539 | 1.825 (1.091–3.055) | 0.022 | 1.065 (0.736–1.541) | 0.739 |
| Others | NA | NA | NA | NA | NA | NA |
| N0 | Ref | 1 | Ref | 1 | Ref | 1 |
| N1 | 0.943 (0.543–1.637) | 0.834 | 0.888 (0.626–1.259) | 0.504 | NS | NS |
| N2 | 0.897 (0.493–1.632) | 0.723 | 1.284 (0.912–1.807) | 0.152 | NS | NS |
| N3 | 0.971 (0.574–1.643) | 0.913 | 1.343 (0.972–1.857) | 0.074 | NS | NS |
| Others | NA | NA | NA | NA | NA | NA |
| I | Ref | 1 | Ref | 1 | Ref | 1 |
| II | 3.265 (0.428–24.917) | 0.254 | 1.338 (0.556–3.219) | 0.515 | NS | NS |
| III | 5.162 (0.692–38.548) | 0.109 | 1.781 (0.749–4.237) | 0.192 | NS | NS |
| IV | 8.019 (0.945–68.084)) | 0.056 | 2.669 (0.989–7.202) | 0.053 | NS | NS |
| Others | NA | NA | NA | NA | NA | NA |
| Yes | Ref | 1 | Ref | 1 | Ref | 1 |
| No | 0.496 (0.347–0.711) | 0.696 (0.560–0.866) | 0.001 | NS | NS | |
| Others | NA | NA | NA | NA | NA | NA |
| Yes | Ref | 1 | Ref | 1 | Ref | 1 |
| No | 0.334 (0.196–0.568) | 0.457 (0.305–0.685) | 0.665 (0.446–0.992) | 0.045 | ||
| Others | NA | NA | NA | NA | NA | NA |
| Bone metastases | ||||||
| Yes | Ref | 1 | Ref | 1 | Ref | 1 |
| No | 0.795 (0.336–1.881) | 0.601 | 0.650 (0.399–1.060) | 0.084 | NS | NS |
| Others | NA | NA | NA | NA | NA | NA |
| Yes | Ref | 1 | Ref | 1 | Ref | 1 |
| No | 0.503 (0.119–2.129) | 0.351 | 0.657 (0.282–1.530) | 0.330 | NS | NS |
| Others | NA | NA | NA | NA | NA | NA |
| Yes | Ref | 1 | Ref | 1 | Ref | 1 |
| No | 2.920 (1.363–6.255) | 0.006 | 4.654 (2.874–7.536) | NS | NS | |
| Unknown | NA | NA | NA | NA | NA | NA |
| Ref – reference; OR – odds ratio; NA – not available; NS – not significant. | ||||||