Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors

23 July 2020: Clinical Research

Xinqiang Zhu ^12ABCDEG* , Kui Yi ^3BE* , Daorong Hou ^4ADF , Hailong Huang ^2BC , Xuetong Jiang ^2ABE , Xiaohong Shi ^2BCE , Chungen Xing ^1AEF*

DOI: 10.12659/MSM.923828

Med Sci Monit 2020; 26:e923828

Table 5 Multivariate analysis of various prognostic parameters in CRC patients with Cox regression analysis.

Prognostic parameters	HR	95% CI	P value
Age (≥65	4.329	1.194–15.695	0.026
Sex (Male Female)	–	–	–
CEA	1.492	.532–4.197	0.447
CA125	3.732	1.371–10.154	0.010
CA19-9	6.045	2.017–18.119	0.001
Tumor grading	16.132	6.673–43.990	0.065
Depth of invasion	0.763	0.413–1.540	0.502
Tumor size (≥5	1.847	0.847–4.578	0.126
Regional lymph nodes (yes no)	5.868	1.546–22.272	0.009
Nerve invasion (yes no)	9.711	2.403–39.243	0.001
Adjuvant chemotherapy (yes no)	4.128	2.226–10.153	0.079
TCN1	1.561	0.941–3.002	0.073
CRC – colorectal cancer; CEA – carcinoembryonic antigen; CA125 – cancer antigen 125; CA19-19 – cancer antigen 19-9.