Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors

23 July 2020: Clinical Research

Xinqiang Zhu ^12ABCDEG* , Kui Yi ^3BE* , Daorong Hou ^4ADF , Hailong Huang ^2BC , Xuetong Jiang ^2ABE , Xiaohong Shi ^2BCE , Chungen Xing ^1AEF*

DOI: 10.12659/MSM.923828

Med Sci Monit 2020; 26:e923828

Table 2 Relationship between TCN1 immunoexpression and clinicopathological characteristics in patients with colorectal cancer.

Parameters		TCN1 immunoexpression level			Statistical results
Parameters		Low	Moderate	Strong	Statistical results
Age	≥65	6	18	21	=−0.250; P=0.803=−0.039; P=0.806
Age		21	18	39	=−0.250; P=0.803=−0.039; P=0.806
Sex	Female	15	15	27	=−0.369; P=0.712
Sex	Male	12	21	33	=−0.369; P=0.712
CEA level	Increased	6	9	36	=−2.909; P=0.004=0.460; P=0.002
CEA level	Normal	21	27	24	=−2.909; P=0.004=0.460; P=0.002
CA125 level	Increased	0	12	15	=−1.043; P=0.297
CA125 level	Normal	27	24	45	=−1.043; P=0.297
CA19-9 level	Increased	3	3	18	=−1.482; P=0.138
CA19-9 level	Normal	24	33	42	=−1.482; P=0.138
Tumor location	Colon	3	3	24	(2.92)=4.525P=0.104
	Distal colon	9	9	9	(2.92)=4.525P=0.104
	Rectum	15	24	27
Histological differentiation	G1	9	15	6	(2.92)=4.976P=0.083
	G2	15	9	24	1−2, 1–3=0.353; P=0.024
	G3	3	12	30
Depth of invasion	T1/T2	15	3	3	=−2.821; P=0.005=0.446; P=0.003
Depth of invasion	T3/T4	12	33	57	=−2.821; P=0.005=0.446; P=0.003
Tumor size	≤5 cm	21	24	21	=−2.341; P=0.01 9=−0.370; P=0.017
Tumor size	>5 cm	6	12	39	=−2.341; P=0.01 9=−0.370; P=0.017
Metastases to regional lymph nodes	No	27	24	15	=−3.845, p
Metastases to regional lymph nodes	Yes	0	12	45	=−3.845, p
Nerve invasion	No	21	18	36	=−0.551; P=0.582
Nerve invasion	Yes	6	18	24	=−0.551; P=0.582
Adjuvant chemotherapy	No	1	2	2	=−0.352; P=0.683
Adjuvant chemotherapy	Yes	36	38	44	=−0.352; P=0.683
CEA – carcinoembryonic antigen; CA125 – cancer antigen 125; CA19-19 – cancer antigen 19-9.