29 June 2020: Animal Study
Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model
Hai-Yan Fu 1EF , Wei-Min Bao 2C , Cai-Xia Yang 1D , Wei-Ju Lai 1D , Jia-Min Xu 1B , Hai-Yan Yu 1B , Yi-Na Yang 1B , Xu Tan 1B , Ajay Kumar Gupta 1F , Ying-Mei Tang 1AG*DOI: 10.12659/MSM.923726
Med Sci Monit 2020; 26:e923726
Supplementary Table 9 The amount of TNF-α secreted by each culture system (unit: pg/mL).
| PBC | Mean | Std | CON | Mean | Std | t | P |
|---|---|---|---|---|---|---|---|
| K1 | 7.03 | 0.852 | K2 | 2.63 | 0.544 | 9.733 | |
| N1 | 3.39 | 0.609 | N2 | 0.53 | 0.349 | 9.111 | |
| K1+N2 | 8.56 | 1.404 | K2+N1 | 6.97 | 1.62 | 1.6585 | 0.1358 |
| K1+L1 | 9.65 | 1.23 | K2+L1 | 3.67 | 0.762 | 9.2416 | |
| K1+L10 | 22.24 | 4.65 | K2+L10 | 15.69 | 2.197 | 2.8479 | 0.0215 |
| K1+N2+L1 | 14.49 | 1.636 | K2+N1+L1 | 6.06 | 1.465 | 8.5835 | |
| K1+N2+L1/T | 7.96 | 0.631 | K2+N1+L1/T | 4.46 | 0.503 | 9.6985 | |
| K1+N2+L10 | 48.78 | 4.67 | K2+N1+L10 | 47.69 | 6.5 | 0.3045 | 0.7685 |
| K1+N2+L10/T | 22.54 | 3.61 | K2+N1+L10/T | 19.28 | 3.47 | 1.4558 | 0.1835 |
| 1 indicates the cells are derived from the PBC group, 2 indicates the cells are derived from the CON group. TNF – tumor necrosis factor; PBC – primary biliary cholangitis; CON – control. | |||||||