24 August 2020>: Database Analysis
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer
Lin Cheng 1ABCDEF* , Zhangmin Tan 2BCDEF* , Zenan Huang 1BCDF , Yuhang Pan 3CDF , Wenhui Zhang 4CDF , Jiani Wang 1ADEG*DOI: 10.12659/MSM.923673
Med Sci Monit 2020; 26:e923673
Table 2 Correlation of MCMs mRNA expression with clinicopathological features for patients with breast carcinoma.
Variables | MCM2 | MCM3 | MCM4 | MCM5 | MCM6 | MCM7 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | mRNA/ p-value | No. | mRNA/ p-value | No. | mRNA/ p-value | No. | mRNA/ p-value | No. | mRNA/ p-value | No. | mRNA/ p-value | |
Age | ||||||||||||
≤51 | 1392 | 0.0149 | 1392 | 1353 | 0.6471 | 1361 | 0.0757 | 1392 | 0.0226 | 1492 | ||
>51 | 2210 | ↓ | 2210 | ↓ | 2055 | – | 2142 | – | 2209 | ↓ | 2263 | ↓ |
Nodal status | ||||||||||||
− | 2493 | 0.4368 | 2493 | 0.0062 | 2380 | 0.0959 | 2447 | 0.4971 | 2493 | 0.7000 | 2447 | 0.1717 |
+ | 1562 | – | 1562 | ↓ | 1494 | – | 1509 | – | 1561 | – | 1761 | – |
ER (IHC) | ||||||||||||
− | 1446 | 1559 | 1519 | 1525 | 1559 | 1583 | ||||||
+ | 3766 | ↓ | 3988 | ↓ | 3836 | ↓ | 3923 | ↓ | 3987 | ↓ | 4104 | ↓ |
PR (IHC) | ||||||||||||
− | 804 | 946 | 936 | 946 | 946 | 1076 | ||||||
+ | 1249 | ↓ | 1439 | ↓ | 1390 | ↓ | 1439 | ↓ | 1439 | ↓ | 1545 | ↓ |
HER2 (IHC) | ||||||||||||
− | 1409 | 0.0436 | 1409 | 0.1203 | 1357 | 0.0419 | 1409 | 0.2175 | 1409 | 0.1689 | 1596 | 0.2159 |
+ | 201 | ↑ | 201 | – | 198 | ↑ | 201 | – | 201 | – | 217 | – |
Triple-negative status | ||||||||||||
Not | 1060 | 1144 | 1094 | 1144 | 1144 | 1144 | ||||||
TNBC | 3942 | ↑ | 4200 | ↑ | 4072 | ↑ | 4200 | ↑ | 4200 | ↑ | 4200 | ↑ |
ER (IHC), PR (IHC) and HER2 (IHC) represent oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 by immunohistochemistry, respectively. TNBC represents basal-like subtype (PAM50) status and/or triple negative breast cancer status by IHC. |