24 August 2020: Database Analysis
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer
Lin Cheng 1ABCDEF* , Zhangmin Tan 2BCDEF* , Zenan Huang 1BCDF , Yuhang Pan 3CDF , Wenhui Zhang 4CDF , Jiani Wang 1ADEG*DOI: 10.12659/MSM.923673
Med Sci Monit 2020; 26:e923673
Table 1 The mRNA transcription level of MCMs in different types of breast carcinoma (BC) compared with normal breast tissues (ONCOMINE database).
| Gene | Types of BC vs. breast | Fold change | p-Value | t-Test | Gene Rank | Ref |
|---|---|---|---|---|---|---|
| MCM2 | Medullary BC | 3.557 | 1.54E-15 | 13.256 | 112 (in top 1%) | Curtis []25 |
| Invasive ductal BC | 2.503 | 3.82E-92 | 34.511 | 214 (in top 2%) | Curtis []25 | |
| BC | 2.062 | 4.52E-6 | 6.693 | 371 (in top 2%) | Curtis []25 | |
| Mixed lobular and ductal BC | 2.200 | 1.18E-6 | 8.165 | 183 (in top 1%) | TCGA* | |
| Invasive lobular BC | 2.120 | 1.06E-12 | 8.432 | 506 (in top 3%) | TCGA* | |
| MCM3 | Medullary BC | 2.101 | 1.62E-11 | 9.579 | 524 (in top 3%) | Curtis []25 |
| MCM4 | Ductal BC | 3.081 | 3.36E-14 | 13.705 | 4 (in top 1%) | Perou []24 |
| Invasive ductal BC | 3.192 | 3.89E-48 | 22.602 | 59 (in top 1%) | TCGA* | |
| Invasive BC | 2.814 | 9.54E-26 | 12.992 | 206 (in top 2%) | TCGA* | |
| Invasive lobular BC | 2.048 | 1.02E-13 | 9.018 | 375 (in top 2%) | TCGA* | |
| Medullary BC | 3.126 | 1.96E-13 | 11.226 | 263 (in top 2%) | Curtis []25 | |
| Invasive BC stroma# | −10.866 | 1.27E-26 | −19.402 | 522 (in top 3%) | Finak []27 | |
| MCM5 | Medullary BC | 2.622 | 2.34E-17 | 15.507 | 48 (in top 1%) | Curtis []25 |
| Intraductal cribriform breast adenocarcinoma | 2.082 | 2.53E-4 | 5.919 | 847 (in top 5%) | TCGA* | |
| Invasive BC stroma# | −4.433 | 4.62E-23 | −20.696 | 836 (in top 5%) | Finak []27 | |
| MCM6 | Ductal BC | 3.149 | 8.27E-9 | 8.698 | 216 (in top 2%) | Richardson []26 |
| Medullary BC | 2.551 | 1.26E-12 | 10.679 | 362 (in top 2%) | Curtis []25 | |
| MCM7 | Medullary BC | 2.196 | 2.81E-11 | 9.248 | 558 (in top 3%) | Curtis []25 |
| * TCGA – The Cancer Genome Atlas – Invasive Breast Carcinoma Gene Expression Data. # The transcription level of MCMs was down-regulated in tumor stroma and normal breast tissues, but up-regulated in breast carcinoma. | ||||||