28 September 2020: Clinical Research
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Wen Li 1ABCE , Jingjing Zhao 2B , Ke Ding 2B , Herta H. Chao 3E , Chiang-Shan R. Li 4BC , Huaidong Cheng 2AG* , Li Shen 5AG*DOI: 10.12659/MSM.923567
Med Sci Monit 2020; 26:e923567
Table 5 Genotype frequencies of SNPs of the 3 genes between the 2 groups.
| SNP | Model | Genotype | ER−/PR− | ER+/PR+ | P* (χ2) | Logistic regression | |
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P** | ||||||
| rs4680 | Codominant | G/G | 70 | 64 | – | – | |
| G/A | 33 | 49 | 0.120 | 0.868 (0.521–1.448) | 0.588 | ||
| A/A | 10 | 6 | 1.842 (0.937–3.62) | 0.076 | |||
| Dominant | G/G | 70 | 64 | 0.208 | 1.403 (0.833–2.362) | 0.204 | |
| G/A+A/A | 43 | 55 | |||||
| Recessive | G/G+G/A | 103 | 113 | 0.253 | 0.633 (0.232–1.723) | 0.370 | |
| A/A | 10 | 6 | |||||
| Additive | – | – | – | – | 1.14 (0.757–1.716) | 0.531 | |
| rs6265 | Codominant | T/T | 23 | 30 | |||
| T/C | 59 | 57 | 0.664 | 1.10 (0.767–1.596) | 0.586 | ||
| C/C | 31 | 32 | 0.834 (0.499–1.396) | 0.490 | |||
| Dominant | T/T | 23 | 30 | 0.379 | 1.008 (0.567–1.792) | 0.978 | |
| T/C+C/C | 90 | 89 | |||||
| Recessive | T/T+T/C | 82 | 87 | 0.926 | 1.29 (0.697–2.389) | 0.418 | |
| C/C | 31 | 32 | |||||
| Additive | – | – | – | – | 1.097 (0.762–1.578) | 0.618 | |
| rs165599 | Codominant | G/G | 35 | 22 | – | – | |
| G/A | 56 | 70 | 0.087 | 1.423 (0.967–2.093) | 0.073 | ||
| A/A | 22 | 27 | 1.418 (0.842–2.387) | 0.190 | |||
| Dominant | G/G | 35 | 22 | 0.027 | 2.019 (1.097–3.717) | 0.024 | |
| G/A+A/A | 78 | 97 | |||||
| Recessive | G/G+G/A | 91 | 92 | 0.548 | 1.245 (0.664–2.335) | 0.494 | |
| A/A | 22 | 27 | |||||
| Additive | – | – | – | – | 1.44 (0.979–2.118) | 0.064 | |
| rs737865 | Codominant | A/A | 58 | 60 | – | – | |
| A/G | 48 | 43 | 0.098 | 1.641 (0.997–2.703) | 0.052 | ||
| G/G | 6 | 16 | 0.519 (0.272–0.991) | 0.047 | |||
| Dominant | A/A | 58 | 60 | 0.836 | 1.056 (0.632–1.767) | 0.834 | |
| A/G+G/G | 54 | 59 | |||||
| Recessive | A/A+A/G | 106 | 103 | 0.036 | 2.888 (1.096–7.612) | 0.032 | |
| G/G | 6 | 16 | |||||
| Additive | – | – | – | – | 1.259 (0.852–1.862) | 0.248 | |
| rs429358 | Codominant | T/T | 93 | 101 | – | – | |
| T/C | 20 | 17 | 0.492 | 3.819e+004 (0-inf) | 0.999 | ||
| C/C | 0 | 1 | 2.01e–005 (0-inf) | 0.999 | |||
| Dominant | T/T | 93 | 101 | 0.597 | 0.813 (0.405–1.63) | 0.559 | |
| T/C+C/C | 20 | 18 | |||||
| Recessive | T/T+T/C | 113 | 118 | 0.329 | 1.521e+009 (0-inf) | 0.999 | |
| C/C | 0 | 1 | |||||
| Additive | – | – | – | – | 0.873 (0.448–1.703) | 0.691 | |
| rs7412 | Codominant | C/C | 93 | 98 | – | – | |
| C/T | 19 | 21 | 0.548 | 2.411e–005 (0-inf) | 0.999 | ||
| T/T | 1 | 0 | 4.511e+004 (0-inf) | 0.999 | |||
| Dominant | C/C | 93 | 98 | 0.992 | 1.033 (0.530–2.016) | 0.923 | |
| C/T+T/T | 20 | 21 | |||||
| Recessive | C/C+C/T | 112 | 119 | 0.304 | 5.73e–010 (0-inf) | 0.999 | |
| T/T | 1 | 0 | |||||
| Additive | – | – | – | – | 0.975 (0.521–1.856) | 0.938 | |
| * χ – test of P values for SNP polymorphism distribution differences between 2 groups; ** P-value for logistic regression analysis; OR – odds ratio (OR); 95% CI – 95% confidence interval; Models – various genetic models that were defined as 1 (MM+Mm) versus 0 (mm) for dominant; 1 (mm) versus 0 (MM+Mm) for recessive; and 0 (mm) versus 1 (Mm) versus 2 (MM) for additive and codominant (M and m represent major and minor alleles, respectively). | |||||||