Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression

28 September 2020: Clinical Research

Wen Li ^1ABCE , Jingjing Zhao ^2B , Ke Ding ^2B , Herta H. Chao ^3E , Chiang-Shan R. Li ^4BC , Huaidong Cheng ^2AG* , Li Shen ^5AG*

DOI: 10.12659/MSM.923567

Med Sci Monit 2020; 26:e923567

Table 4 Sequencing of the 3 genes in the 2 groups.

SNP	COMT			APOE		BDNF
SNP	rs4680	rs165599	rs737865	rs429358	rs7412	rs6265
CHR	22	22	22	19	19	11
Allele position	19951271	19956781	19930121	45411941	45412079	27679916
Ref allele	G	G	A	T	C	C
Alt allele	A	A	G	C	T	T
MAF	0.256	0.479	0.315	0.080	0.088	0.492
P for HWE	0.480	0.183	0.469	0.586	0.472	0.977
*	0.586	0.091	0.264	0.492	0.860	0.663
SNP – single-nucleotide polymorphism; CHR – chromosome; Ref allele – alleles in the on the reference sequence; Alt allele – the other (alternative) allele on the locus of the Ref allele; MAF – minor allele frequency (data from 1000 Genomes); HWE – Hardy-Weinberg equilibrium; P for HWE – -value for HWE in 2 groups; – -value for allele frequency differences between the 2 groups.