04 August 2020: Database Analysis
Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach
Shuang Song 12ABCDEF , Bin Li 12A , Zhen Jia 12C , Li Guo 12AG*DOI: 10.12659/MSM.923547
Med Sci Monit 2020; 26:e923547
Table 2 Summary of the GEO2R analysis of the sirtuin mRNA levels between the Alzheimer’s disease and control groups in 8 datasets.
| Gene symbol | Number of downregulated datasets | Number of upregulated datasets | Total number of datasets | Adjusted P value | P value | t | B | Log2FC | Datasets with most significant adjusted P value (GEO ID) |
|---|---|---|---|---|---|---|---|---|---|
| SIRT1 | 0 | 8 | 8 | 2.29E-25 | 3.43E-26 | 11.26 | 48.51 | 8.83E-02 | GSE33000 |
| SIRT2 | 1 | 6 | 8 | 3.85E-06 | 4.19E-07 | 5.24 | 5.94 | 2.74E-01 | GSE132903 |
| SIRT3 | 7 | 0 | 8 | 8.49E-30 | 9.62E-31 | −12.40 | 58.90 | −8.21E-02 | GSE33000 |
| SIRT4 | 0 | 3 | 7 | 6.53E-17 | 1.53E-18 | 9.59 | 31.44 | 1.37E-01 | GSE44768 |
| SIRT5 | 7 | 0 | 8 | 2.26E-43 | 8.33E-45 | −15.67 | 91.06 | −1.42E-01 | GSE33000 |
| SIRT6 | 2 | 2 | 8 | 1.39E-05 | 1.98E-06 | 4.83 | 4.38 | 2.07E-01 | GSE15222 |
| SIRT7 | 0 | 6 | 8 | 3.95E-24 | 6.38E-25 | 10.93 | 45.62 | 9.93E-02 | GSE33000 |