15 July 2020: Clinical Research
Radiofrequency Ablation (RFA) Combined with Transcatheter Arterial Chemoembolization (TACE) for Patients with Medium-to-Large Hepatocellular Carcinoma: A Retrospective Analysis of Long-Term Outcome
Weiwen Liu 1ABC , Huihong Xu 2DE , Xihui Ying 1EFG , Dengke Zhang 1CD , Linqiang Lai 1BC , Linyou Wang 3EF , Jianfei Tu 1CFG* , Jiansong Ji 1BDG*DOI: 10.12659/MSM.923263
Med Sci Monit 2020; 26:e923263
Table 2 Univariate and multivariate cox model for OS and PFS (this analysis was done in the TACE plus RFA group).
| OS | PFS | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR | P | HR | P | HR | P | HR | P | |
| Age (≤60, >60) | 1.115 (0.704–1.765) | 0.642 | 1.137 (0.753–1.718) | 0.540 | ||||
| Gender (Male, female) | 0.718 (0.367–1.406) | 0.334 | 0.679 (0.369–1.250) | 0.214 | ||||
| Hepatitis B (yes, no) | 0.626 (0.345–1.136) | 0.123 | 2.323 (1.096–4.923) | 0.028 | 0.560 (0.335–0.936) | 0.027 | 2.089 (1.078–4.048) | 0.029 |
| Cirrhosis (yes, no) | 0.637 (0.405–1.003) | 0.051 | 0.744 (0.494–1.120) | 0.156 | ||||
| History of surgery | 1.036 (0.585–1.835) | 0.904 | 1.179 (0.689–2.016) | 0.548 | ||||
| Tumor size (≤5 cm, 5–10 cm) | 0.523 (0.328–0.8351) | 0.007 | 1.952 (1.213–3.143) | 0.006 | 0.746 (0.493–1.129) | 0.166 | ||
| No. nodules (one, more) | 1.391 (0.885–2.187) | 0.152 | 0.962 (0.636–1.454) | 0.854 | ||||
| Child-Pugh stage | 1.486 (0.650–3.397) | 0.348 | 1.216 (0.599–2.466) | 0.589 | ||||
| BCLC stage (A, B) | 0.952 (0.584–1.553) | 0.844 | 1.000 (0.643–1.556) | 0.998 | ||||
| TACE times (1, >1) | 0.577 (0.370–0.898) | 0.015 | 1.867 (1.156–3.013) | 0.011 | 0.624 (0.417–0.933) | 0.021 | 1.646 (1.081–2.507) | 0.020 |
| Complete ablation (yes, no) | 0.685 (0.402–1.168) | 0.165 | 0.884 (0.551–1.419) | 0.610 | ||||
| AFP (ng/ml) (≤200, >200) | 0.419 (0.256–0.685) | 0.001 | 2.426 (1.533–3.839) | 0.550 (0.349–0.866) | 0.010 | 1.732 (1.136–2.639) | 0.011 | |
| ALT (U/L) (≤40, >40) | 0.965 (0.614–1.518) | 0.878 | 1.038 (0.690–1.560) | 0.859 | ||||
| AST (U/L) (≤40, >40) | 0.537 (0.340–0.849) | 0.008 | 1.946 (1.196–3.166) | 0.007 | 0.610 (0.407–0.915) | 0.017 | 1.741 (1.144–2.650) | 0.010 |