Special AT-rich Sequence Binding-Protein 1 (SATB1) Correlates with Immune Infiltration in Breast, Head and Neck, and Prostate Cancer

Hua Ge; Yan Yan; Maozhao Yan; Lingfei Guo; Kun Mao

doi:10.12659/MSM.923208

20 June 2020: Database Analysis

Special AT-rich Sequence Binding-Protein 1 (SATB1) Correlates with Immune Infiltration in Breast, Head and Neck, and Prostate Cancer

Hua Ge ^1ABCDEF* , Yan Yan ^2BCDE , Maozhao Yan ^1CEF , Lingfei Guo ^1EF , Kun Mao ^1CF

DOI: 10.12659/MSM.923208

Med Sci Monit 2020; 26:e923208

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Table 4 Correlation analysis between SATB1 and relate genes and markers of immune cells in TIMER.

Description	Gene marker	BRCA				HNSC				PRAD
		None		Purity		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P	Cor	P	Cor	P
CD8+ T cell	CD8A	0.231	^***	0.114	^***	0.276	^***	0.248	^***	0.127	^**	0.047	0.339
CD8+ T cell	CD8B	0.222	^***	0.117	^***	0.300	^***	0.267	^***	0.012	0.781	−0.039	0.430
T cell (general)	CD3D	0.212	^***	0.081	^*	0.199	^***	0.160	^***	0.035	0.437	−0.132	^**
	CD3E	0.241	^***	0.108	^***	0.344	^***	0.327	^***	0.046	0.311	−0.042	0.387
	CD2	0.225	^***	0.096	^**	0.311	^***	0.287	^***	0.051	0.255	−0.041	0.402
B cell	CD19	0.193	^***	0.078	^*	0.330	^***	0.312	^***	−0.003	0.942	−0.178	^***
B cell	CD79A	0.234	^***	0.108	^***	0.386	^***	0.375	^***	0.017	0.713	−0.046	0.352
Monocyte	CD86	0.165	^***	0.058	0.067	0.242	^***	0.221	^***	0.030	0.499	−0.069	0.161
Monocyte	CD115 (CSF1R)	0.225	^***	0.108	^***	0.381	^***	0.376	^***	0.161	^***	0.068	0.167
TAM	CCL2	0.206	^***	0.115	^***	0.343	^***	0.323	^***	0.062	0.168	0.000	0.997
	CD68	0.090	^**	−0.114	0.660	0.126	^**	0.114	^*	0.064	0.154	0.146	^**
	IL10	0.169	^***	0.063	^*	0.266	^***	0.253	^***	0.123	^**	0.080	0.102
M1 Macrophage	INOS (NOS2)	0.182	^***	0.162	^***	0.372	^***	0.377	^***	0.175	^***	0.115	^*
	IRF5	−0.002	0.938	−0.073	^*	0.104	^*	0.100	^*	0.153	^***	−0.124	^*
	COX2 (PTGS2)	0.384	^***	0.311	^***	0.018	0.689	0.019	0.671	0.308	^***	0.240	^***
M2 Macrophage	CD163	0.156	^***	0.068	^*	0.284	^***	0.277	^***	0.095	^*	0.019	0.704
	VSIG4	0.132	^***	0.041	0.198	0.269	^***	0.261	^***	0.004	0.373	0.047	0.337
	MS4A4A	0.186	^***	0.070	^*	0.282	^***	0.268	^***	−0.004	0.369	−0.127	^**
Neutrophils	CD66b (CEACAM8)	0.076	^*	0.101	^**	0.112	^*	0.105	^*	0.027	0.541	0.023	0.636
	CD11b (ITGAM)	0.155	^***	0.065	^*	0.445	^***	0.428	^***	0.212	^***	0.127	^**
	CCR7	0.370	^***	0.231	^***	0.493	^***	0.464	^***	0.649	^***	0.566	^***
Natural killer cell	KIR2DL1	0.384	^***	0.315	^***	0.248	^***	0.242	^***	−0.033	0.463	−0.083	0.092
	KIR2DL3	0.117	^***	0.058	0.068	0.210	^***	0.191	^***	−0.044	0.324	−0.017	0.733
	KIR2DL4	0.133	^***	0.061	0.056	0.115	^**	0.119	^**	0.084	0.061	0.084	0.087
	KIR3DL1	0.168	^***	0.100	^**	0.218	^***	0.209	^***	0.062	0.166	0.035	0.478
	KIR3DL2	0.181	^***	0.098	^**	0.302	^***	0.287	^***	0.148	^***	0.134	^**
	KIR3DL3	0.101	^***	0.065	^*	0.088	^*	0.070	0.123	0.045	0.315	0.053	0.282
	KIR2DS4	0.149	^***	0.086	^**	0.115	^**	0.101	^*	0.024	0.586	−0.042	0.387
Dendritic cell	HLA-DPB1	0.176	^***	0.027	0.396	0.274	^***	0.252	^***	0.116	^**	−0.217	^***
	HLA-DQB1	0.142	^***	0.039	0.217	0.193	^***	0.166	^***	0.033	0.466	−0.106	^*
	HLA-DRA	0.199	^***	0.072	^*	0.296	^***	0.276	^***	0.053	0.235	−0.047	0.342
	HLA-DPA1	0.191	^***	0.056	0.076	0.313	^***	0.291	^***	0.042	0.344	−0.061	0.215
Dendritic cell (cintinued)	BDCA-1(CD1C)	0.275	^***	0.161	^***	0.389	^***	0.372	^***	0.201	^***	0.104	^*
	BDCA-4(NRP1)	0.309	^***	0.235	^***	0.314	^***	0.316	^***	0.034	0.449	0.028	0.566
	CD11c (ITGAX)	0.184	^***	0.074	^*	0.336	^***	0.330	^***	−0.024	0.599	−0.065	0.187
Th1	T-bet (TBX21)	0.230	^***	0.109	^***	0.267	^***	0.237	^***	−0.009	0.849	−0.064	0.190
	STAT4	0.320	^***	0.207	^***	0.267	^***	0.246	^***	0.093	^*	0.021	0.674
	STAT1	0.089	^**	0.039	0.222	0.019	0.670	0.000	0.998	0.281	^***	0.240	^***
	IFN-γ (IFNG)	0.172	^***	0.080	^*	0.069	0.118	0.028	0.540	0.031	0.489	0.003	0.948
	TNF-α (TNF)	0.147	^***	0.111	^***	−0.034	0.444	−0.040	0.372	0.070	0.119	−0.028	0.570
Th2	GATA3	−0.308	^***	−0.251	^***	0.202	^***	0.182	^***	0.196	^***	0.115	^*
	STAT6	0.022	0.468	−0.023	0.478	0.100	^**	0.105	^*	0.327	^***	0.311	^***
	STAT5A	0.219	^***	0.141	^***	0.215	^***	0.189	^***	0.072	0.108	−0.004	0.929
	IL13	0.085	^**	0.041	0.196	0.165	^***	0.147	^**	0.053	0.238	−0.030	0.542
Tfh	BCL6	0.081	0.069	0.053	0.096	0.341	^***	0.356	^***	0.131	^**	0.137	^**
Tfh	IL21	0.150	^***	0.083	^**	0.335	^***	0.300	^***	0.015	0.731	0.017	0.732
Th17	STAT3	0.182	^***	0.162	^***	0.320	^***	0.321	^***	0.448	^***	0.412	^***
Th17	IL17A	0.117	^***	0.078	^*	0.151	^***	0.131	^**	0.148	^***	0.033	0.504
Treg	FOXP3	0.187	^***	0.094	^**	0.504	^***	0.506	^***	0.159	^***	0.145	^**
	CCR8	0.195	^***	0.124	^***	0.565	^***	0.563	^***	0.323	^***	0.294	^***
	STAT5B	0.247	^***	0.207	^***	0.449	^***	0.437	^***	0.433	^***	0.434	^***
	TGFβ (TGFB1)	0.097	^**	−0.018	0.568	−0.201	^***	−0.200	^***	−0.085	0.058	−0.119	^*
T cell exhaustion	PD-1 (PDCD1)	0.164	^***	0.041	0.194	0.236	^***	0.212	^***	0.054	0.232	0.100	^*
	CTLA4	0.211	^***	0.114	^***	0.224	^***	0.196	^***	−0.008	0.856	−0.046	0.352
	LAG3	0.062	^*	−0.004	0.900	0.008	0.067	0.005	0.272	−0.152	^***	−0.180	^***
	TIM-3 (HAVCR2)	0.123	^***	0.014	0.651	0.297	^***	0.280	^***	−0.007	0.120	−0.152	^**
	GZMB	0.188	^***	0.009	^**	0.063	0.152	0.026	0.564	−0.021	0.644	−0.093	0.057
TIMER – Tumor Immune Estimation Resource; BRCA – breast invasive carcinoma; HNSC – head and neck squamous cell carcinoma; PRAD – prostate adenocarcinoma; TAM – tumor-associated macrophages; Th – T helper cell; Tfh – follicular helper T cell; Treg – regulatory T cell; Cor – R value of Spearman’s correlation; None – correlation without adjustment. Purity – correlation adjusted by purity. ^* ^ ^*

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Special AT-rich Sequence Binding-Protein 1 (SATB1) Correlates with Immune Infiltration in Breast, Head and Neck, and Prostate Cancer

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