22 June 2020: Clinical Research
Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults
Jialin Li 1CE , Xi’ai Wu 2BD , Minjing Luo 1BF , Meihua Yan 3BD , Qian Wang 1D , Ping Li 3AG* , Wenquan Niu 3CE*DOI: 10.12659/MSM.922910
Med Sci Monit 2020; 26:e922910
Table 4 Interaction between free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) in prediction of chronic kidney disease (CKD) at different stages.
| Interaction items | OR, 95% CI, P | ||||
|---|---|---|---|---|---|
| CKD Stage 1–2 | CKD Stage 3 | CKD Stage 4 | CKD Stage 5 | ||
| FT3–FT4 | High FT3– High FT4 | Ref. | Ref. | Ref. | Ref. |
| High FT3– Low FT4 | 2.12, 1.14 to 3.94, 0.018 | 1.13, 0.51 to 2.49, 0.768 | 1.58, 0.87 to 2.86, 0.133 | 1.81, 1.30 to 2.55, | |
| Low FT3– High FT4 | 5.33, 1.58 to 18.03, 0.007 | 2.01, 0.56 to 7.22, 0.283 | 4.10, 1.26 to 13.3, 0.019 | 17.72, 7.18 to 43.74, | |
| Low FT3–Low FT4 | 11.93, 4.34 to 32.83, | 3.63, 1.14 to 9.93, 0.012 | 10.7, 4.37 to 26.23, | 22.28, 9.68 to 51.30, | |
| FT3–TSH | High FT3–Low TSH | Ref. | Ref. | Ref. | Ref. |
| High FT3–High TSH | 0.99, 0.50 to 1.97, 0.986 | 1.25, 0.59 to 2.66, 0.549 | 1.74, 1.06 to 2.85, 0.028 | 0.94, 0.52 to 1.72, 0.842 | |
| Low FT3–Low TSH | 7.68, 1.63 to 36.16, 0.010 | 12.17, 1.17 to 126.08, 0.036 | 4.30, 0.78 to 23.64, 0.094 | 15.93, 6.12 to 41.49, | |
| Low FT3–High TSH | 2.19, 0.33 to 14.49, 0.415 | 9.20, 1.12 to 75.61, 0.039 | 9.13, 1.63 to 51.25, 0.012 | 19.92, 5.88 to 67.53, | |
| FT4–TSH | High FT4–Low TSH | Ref. | Ref. | Ref. | Ref. |
| High FT4–High TSH | 0.96, 0.43 to 2.17, 0.922 | 1.36, 0.57 to 3.23, 0.478 | 2.24, 1.24 to 4.05, 0.008 | 1.77, 1.08 to 2.90, 0.022 | |
| Low FT4–Low TSH | 2.39, 0.80 to 7.13, 0.117 | 5.58, 1.62 to 19.09, 0.006 | 2.68, 1.22 to 5.93, 0.015 | 3.59, 1.91 to 6.75, | |
| Low FT4–High TSH | 1.54, 0.51 to 4.60, 0.437 | 5.51, 1.56 to 19.44, 0.008 | 3.24, 1.52 to 6.91, 0.002 | 4.36, 2.38 to 7.96, | |
| OR – odds ratio; 95% CI – 95% confidence interval; Ref. – reference group. FT3, FT4, and TSH were binarized according to the median values (FT3: 2.18 pg/mL, FT4: 1.13 ng/dL, TSH: 2.06 μIU/mL) in all study participants, and classified into high and low groups, respectively. | |||||