Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults

22 June 2020: Clinical Research

Jialin Li ^1CE , Xi’ai Wu ^2BD , Minjing Luo ^1BF , Meihua Yan ^3BD , Qian Wang ^1D , Ping Li ^3AG* , Wenquan Niu ^3CE*

DOI: 10.12659/MSM.922910

Med Sci Monit 2020; 26:e922910

Table 3 Prediction accuracy gained by adding thyroid hormones to basic model for chronic kidney disease (CKD) at different stages.

Statistics	CKD Stage 1–2				CKD Stage 3
Statistics	Basic model	Basic model plus FT3	Basic model plus FT4	Basic model plus TSH	Basic model	Basic model plus FT3	Basic model plus FT4	Basic model plus TSH

AIC	924.6	376.6	486.4	267.7	904.4	321	453.2	307.6
BIC	961.1	411.6	521.4	297.3	942.1	357	489.2	339.6
LR test (χ)	Ref.	111.97	2.21	0.02	Ref.	137.2	5.02	2.09
LR test P value	Ref.		0.1374	0.8994	Ref.		0.025	0.1478

NRI (P value)	Ref.		0.00618	0.00126	Ref.		0.0009	0.0074
IDI (P value)	Ref.			0.00105	Ref.			0.1767
Statistics	CKD Stage 4				CKD Stage 5
Statistics	Basic model	Basic model plus FT3	Basic model plus FT4	Basic model plus TSH	Basic model	Basic model plus FT3	Basic model plus FT4	Basic model plus TSH

AIC	1151.7	455.2	649	434.7	1310.2	793	790.6	499.2
BIC	1194.1	497	690.8	473.4	1359.1	841.8	839.4	545.1
LR test (χ)	Ref.	208.16	14.35	8.34	Ref.	5.72	8.19	11.69
LR test P value	Ref.		0.0002	0.0039	Ref.	0.0168	0.0042	0.0006

NRI (P value)	Ref.				Ref.			0.0003
IDI (P value)	Ref.				Ref.
AIC – Akaike information criterion; BIC – Bayesian information criterion; LR – likelihood ratio; NRI – net reclassification improvement; IDI – integrated discrimination improvement; FT3 – free triiodothyronine; FT4 – free thyroxine; TSH – thyroid-stimulating hormone; Ref. – reference group. Basic model included age, gender, diabetes, hypertension, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and uric acid.