13 June 2020: Database Analysis
Comprehensive Analysis of Competing Endogenous RNA (ceRNA) Network Based on RNAs Differentially Expressed in Lung Adenocarcinoma Using The Cancer Genome Atlas (TCGA) Database
Huaihui Tang 1ABCDEF , Zhongshuai Wang 2F , Qianqian Shao 3F , Yue Wang 1FG , Qingshan Yang 1AEG*DOI: 10.12659/MSM.922676
Med Sci Monit 2020; 26:e922676
Table 1 Results of mRNAs GO enrichment analysis in the ceRNA network.
| Category | Term | Count | Genes | FDR |
|---|---|---|---|---|
| MF | GO: 0043565~sequence-specific DNA binding | 33 | HOXA13, HOXA11, PAX3, NR2E1, HOXA1, HOXC8, LHX2, HOXA10, LHX5, POU4F1, FOXD1, NKX2-2, TLX1, PITX2, FOXL2, ERG, TBX3, OTX1, EMX2, HNF4G, EN2, NR4A3, FOXN4, SALL3, SHOX2, SALL4, HNF4A, HOXB7, SALL1, FOXG1, TFAP2B, TFAP2A, NEUROD1 | 9.42E-08 |
| MF | GO: 0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 18 | FOXL2, ONECUT1, OTX1, NR4A3, HMGA2, MYBL2, NR2E1, HNF4A, HOXA10, TFAP2B, NEUROD1, TFAP2A, POU4F1, POU3F2, FOXD1, TLX1, KLF4, PITX2 | 3.98E-04 |
| MF | GO: 0003700~transcription factor activity, sequence-specific DNA binding | 35 | E2F2, E2F7, E2F8, PAX3, MYBL2, NR2E1, TAL1, HOXC8, PAX9, OVOL1, POU3F2, FOXD1, NKX2-2, PITX2, FOXL2, ERG, TBX3, RCOR2, OTX1, TBX4, HNF4G, HMGA1, FOXN4, MYCN, SALL3, DLX2, SALL4, HNF4A, HOXB7, SALL1, TFAP2B, NEUROD1, TFAP2A, TBX18, KLF4 | 0.017886388 |
| BP | GO: 0034765~regulation of ion transmembrane transport | 11 | KCNQ5, HCN2, KCNQ3, KCNJ6, SCN3A, CLIC5, CACNA1E, KCNJ10, SCN7A, KCNA7, KCNK10 | 0.027067873 |
| GO – Gene Ontology; mRNAs – messenger RNAs; ceRNAs – competing endogenous RNAs; MF – molecular function; BP – biological process. ( | ||||