Development and Validation of Prognostic Nomograms for Patients with Duodenal Neuroendocrine Neoplasms

21 June 2020: Database Analysis

Shenghong Sun ^BDEF* , Wei Wang ^ACDFG** , Chiyi He ^ABG*

DOI: 10.12659/MSM.922613

Med Sci Monit 2020; 26:e922613

Table 2 Univariate and multivariate analyses of OS in patients with D-NENs.

Characteristics		Overall survival
		Univariate analysis			Multivariate analysis
		HR	95% CI	P	HR	95% CI	P
Age		Ref			Ref
Age	≥65	3.386	2.276–5.038		3.626	2.379–5.527
Race	White	Ref			Ref
	Black	1.084	0.723–1.625	0.698	1.076	0.703–1.647	0.736
	Other	0.757	0.350–1.640	0.481	0.549	0.246–1.224	0.142
Gender	Female	Ref			Ref
Gender	Male	0.980	0.686–1.401	0.913	1.057	0.721–1.548	0.778
Marital status	Married	Ref			Ref
	Unmarried	1.640	1.135–2.368		1.699	1.146–2.520
	Unknown	1.513	0.688–3.329	0.304	1.674	0.749–3.743	0.210
Year of diagnosis	1988–2009	Ref			Ref
Year of diagnosis	2010–2015	0.578	0.388–0.861		0.502	0.331–0.761
Tumor grade	1	Ref
	2	1.289	0.789–2.103	0.311	1.220	0.726–2.050	0.453
	3/4	4.535	2.653–7.752		3.894	2.054–7.382
Tumor size		Ref			Ref
	1–2 cm	1.232	0.817–1.858	0.320	1.636	0.992–2.701	0.054
	>2 cm	1.753	1.104–2.784		2.018	1.002–4.063
T stage	T1	Ref			Ref
	T2	0.984	0.649–1.492	0.940	0.701	0.412–1.192	0.189
	T3	1.193	0.628–2.268	0.589	0.683	0.263–1.776	0.434
	T4	2.629	1.417–4.878		1.397	0.580–3.365	0.456
N stage	N0	Ref			Ref
N stage	N1	1.072	0.680–1.688	0.766	0.950	0.510–1.770	0.873
M stage	M0	Ref			Ref
M stage	M1	1.242	0.578–2.668	0.578	1.373	0.607–3.104	0.447
Surgery	Yes	Ref			Ref
Surgery	No/Unknown	2.330	1.512–3.591		1.805	1.116–2.920
D-NENs – primary duodenal neuroendocrine neoplasms; Race: Other – American Indian & AK Native & Asian & Pacific Islander; Marital status: Unmarried – Single & Separated & Divorced & Widowed & Unmarried or Domestic Partner.