21 August 2020>: Animal Study
Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model
Minghong Deng 1ACE , Chunwang Lin 1AE* , Xianglin Zeng 1C , Jianping Zhang 1BD , Fang Wen 1C , Ziguang Liu 2B , Haiyan Wu 3B , Xiaofeng Wu 4BDOI: 10.12659/MSM.922429
Med Sci Monit 2020; 26:e922429
Table 2 Determination of predictive abilities of p53, p521 and caspase-3 IRS values for CASMC apoptosis in KD mice.
Parameter | p53 IRS | p21 IRS | Caspase-3 IRS |
---|---|---|---|
AUC | 0.889 | 0.997 | 0.976 |
95% CI | 0.758–1.000 | 0.735–1.000 | 0.615–0.998 |
Sensitivity | 0.917 | 1.000 | 0.917 |
Specificity | 0.750 | 0.917 | 1.000 |
Positive likelihood ratio | 11.6 | 12 | 11.8 |
Optimal cut-off, score | 4.15 | 4.18 | 4.22 |