Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer

17 June 2020: Database Analysis

Jin Zhu ^1AG* , Lu Jin ^1CEF* , Aili Zhang ^2BCD* , Peng Gao ^1DF , Guangcheng Dai ^1BF , Ming Xu ^1CF , Lijun Xu ^1AD* , Dongrong Yang ^1AEG*

DOI: 10.12659/MSM.922346

Med Sci Monit 2020; 26:e922346

Table 2 Functional enrichment of EZH2 coexpressed genes.

Term	Count	P-value	Fold	FDR

GO: 0022403 – cell cycle phase	89	4.47E-90	17.3	6.86E-87
GO: 0000279 – M phase	82	1.06E-87	20.1	1.62E-84
GO: 0022402 – cell cycle process	94	6.78E-85	13.4	1.04E-81
Cluster 2, Score: 72.7
GO: 0000278 – mitotic cell cycle	78	1.05E-76	17.0	1.61E-72
GO: 0007067 – mitosis	65	5.08E-73	23.8	7.80E-70
GO: 0000280 – nuclear division	65	5.08E-73	23.8	7.80E-70
GO: 0000087 – M-phase of mitotic cell cycle	65	1.91E-72	23.4	2.94E-69
GO: 0048285 – organelle fission	65	9.64E-72	22.9	1.48E-68

GO: 0006974 – response to DNA damage stimulus	34	2.32E-19	7.4	3.57E-16
GO: 0006281 – DNA repair	28	9.77E-17	7.9	1.67E-13
GO: 0033554 – cellular response to stress	34	5.96E-14	4.8	9.14E-11

GO: 0051327 – M phase of meiotic cell cycle	16	9.41E-13	13.1	1.45E-09
GO: 0007126 – meiosis	16	9.41E-13	13.1	1.45E-09
GO: 0051321 – meiotic cell cycle	16	1.28E-12	12.9	1.96E-09
Cluster – annotation cluster; Score – enrichment score; Fold – fold enhancement; FDR – false discovery rate.