Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy

22 June 2020: Clinical Research

Jie Wang ^1ABC* , Yajun Wang ^2BC* , Xudong Xu ^3BC* , Sheng Peng ^4CD , Feng Xu ^5CD* , Peirong Liu ^4AEF*

DOI: 10.12659/MSM.922028

Med Sci Monit 2020; 26:e922028

Table 3 Serum levels of BDNF and 5-HT at various timepoints after surgery.

Variables	High-dose S-ketamine, n=104	Low-dose S-ketamine, n=104	Racemic ketamine, n=104	Control, n=105	P value

Before	23.24±1.29	23.08±1.29	23.23±1.36	23.23±1.18	0.775
1 d	22.58±1.52,,^b	20.36±1.38,^a	20.17±1.32,^a	19.11±1.16,,^a
2 d	23.86±1.35,,^b	21.55±1.42,^a	21.63±1.26,^a	20.04±1.15,,^a
3 d	24.95±1.54,,^b	23.52±1.18,^a	23.36±1.21,^a	21.20±1.03,,^a
5 d	24.55±2.00^d	24.71±1.52^d	24.64±1.71^d	23.46±1.49,,^a
7 d	27.01±1.36	26.47±1.14	26.59±1.17	26.61±1.15	0.035

Before	228.83±17.70	228.10±16.84	226.40±16.91	222.87±17.22	0.059
1 d	252.38±15.89,,^b	246.13±14.48,^a	248.25±13.32,^a	227.04±15.69,,^a
2 d	261.98±17.65,,^b	247.81±18.57,^a	247.51±17.93,^a	232.16±19.31,,^a
3 d	270.39±23.61,,^b	255.37±18.57,^a	250.13±18.58,^a	235.94±21.48,,^a
5 d	335.32±20.30^d	336.47±21.63^d	339.03±23.24^d	305.02±21.48,,^a
7 d	347.05±26.23	353.41±26.47	345.41±27.66	345.24±24.85	0.085
^a P ^b P ^c P ^d P Continuous data were compared using ANOVA followed by Tukey post hoc test.