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26 November 2021 : Review article  

[In Press] A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer

Jiang Min1EF, Huilin Zhou1F, Su Jiang2F, Hong Yu1AEG

DOI: 10.12659/MSM.934106

Med Sci Monit In Press; DOI: 10.12659/MSM.934106  

Available online: 2021-11-26, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

ABSTRACT
Circulating tumor DNA (ctDNA) is a type of cell-free DNA released by tumor cells after necrosis and apoptosis, and it can be actively secreted by tumor cells. Since ctDNA is derived from various tumor sites, it can provide far more comprehensive genomic and epigenomic information than a single-site biopsy. Therefore, ctDNA can overcome tumor heterogeneity, which is the major limitation of a traditional tissue biopsy approach. Noninvasive ctDNA assays allow continuous real-time monitoring of the molecular status of cancers. Recently, ctDNA assays have been widely used in clinical practice, including cancer diagnosis, evaluation of therapeutic efficacy and prognosis, and monitoring of relapse and metastasis. Although ctDNA shows a high diagnostic performance in advanced esophageal cancer, it is far from satisfactory for early diagnosis of esophageal cancer. Monitoring the dynamic changes of ctDNA is beneficial for the evaluation of therapeutic efficacy and prediction of early recurrence in esophageal cancer. It is necessary to establish standards for individualized ctDNA detection in the evaluation of treatment response and surveillance of esophageal cancer and to develop clinical practice guideline for the systemic treatment of patients with “ctDNA recurrence.” This review aims to provide an update on the role of ctDNA in the diagnosis and monitoring of esophageal cancer.

Keywords: Circulating Tumor DNA; Diagnosis; Esophageal Neoplasms; High-Throughput Nucleotide Sequencing; Prognosis

Editorial

01 January 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

SARS-CoV-2/COVID-19

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Med Sci Monit In Press; DOI: 10.12659/MSM.935474  

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Med Sci Monit In Press; DOI: 10.12659/MSM.935567  

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In Press

28 Jan 2022 : Database Analysis  

Evaluation of Structural Neural Connectivity Between the Primary Auditory Cortex and Cognition-Related Brai...

Med Sci Monit In Press; DOI: 10.12659/MSM.936131  

27 Jan 2022 : Clinical Research  

Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary...

Med Sci Monit In Press; DOI: 10.12659/MSM.935002  

25 Jan 2022 : Editorial  

Editorial: The 2022 World Health Organization (WHO) Priority Recommendations and Response to the Omicron Va...

Med Sci Monit In Press; DOI: 10.12659/MSM.936199  

25 Jan 2022 : Clinical Research  

Experience of the Polish Medical Air Rescue Service During the First Year of the COVID-19 Pandemic and Meas...

Med Sci Monit In Press; DOI: 10.12659/MSM.935474  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750