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11 October 2021 : Clinical Research

[In Press] Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors

Qiao-Qiao Wang1BEG, Cha-Ying He2AC, Jin Mei3ADF, Yi-Lin Xu4BC

DOI: 10.12659/MSM.933782

Med Sci Monit In Press; DOI: 10.12659/MSM.933782  

Available online: 2021-10-11, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
This study aimed to survey the overall situation of birth defects (BDs) among citizens of Hangzhou, China, and the risk factors of different BD types.
MATERIAL AND METHODS
We collected the data of 4349 perinatal infants with BDs in Hangzhou. The potentially associated risk factors of BDs were recorded and logistic regression analysis was used to predict the high incidence of BDs.
RESULTS
Among all perinatal infants with BDs, there were 4105 (94.3%) single births, 225 (5.2%) twin births, and 10 (0.2%) multiple births. In clinical outcomes, there were 2477 (57.0%) live births, 1806 (41.5%) dead fetuses, and 11 (0.3%) stillbirths. Down syndrome ranked first, accounting for 30.7% of the total births, followed by cleft lip and polydactyly. Low family income, nulliparity, high parity, high education level, and taking contraceptives in early pregnancy were found to be risk factors of Down syndrome. Low parity, low education level, and pesticide exposure were found to be risk factors of cleft lip. For polydactyly, young age of the mother and a parity above 0 were identified as risk factors.
CONCLUSIONS
Different risks factors can influence BD development and potentially help to predict specific BD types, such as demographic features and harmful exposure in early pregnancy.

Keywords: Fetal Alcohol Spectrum Disorders; Gaucher Disease, Perinatal Lethal; Jaundice, Neonatal; Teratogenesis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750