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22 October 2021 : Clinical Research  

[In Press] Correlation Between Severity of Illness and Levels of Free Triiodothyronine, Interleukin-6, and Interleukin-10 in Patients with Acute Pancreatitis

Fei Tian1ABCDEFG, Tianjiao Lin1ABCDEF, Qingyun Zhu1ABC, Youdong Wan1ABC, Ziqian Wu1C, Shaoyan Lv1C, Jingyu Song1C, Ruomeng Li2BE, Yunyun Wang1E, Yushi Zhang1D, Xu Yan1E, Xinting Pan1ABCDEFG

DOI: 10.12659/MSM.933230

Med Sci Monit In Press; DOI: 10.12659/MSM.933230  

Available online: 2021-10-22, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Acute pancreatitis (AP) is a common acute abdominal disease. Rapid evaluation of the severity is important for AP prognosis and treatment. Free triiodothyronine (fT3) level is associated with the prognosis of AP patients. This study aimed to investigate the fT3 level in patients with acute pancreatitis; early warning signs of inflammation, including interleukin-6 (IL-6) and interleukin-10 (IL-10); and the correlation of fT3 level with illness severity.
MATERIAL AND METHODS
Enrolled AP patients (N=312) were divided into an SAP group (N=92) and a non-SAP group (N=220) according to the Revision of Atlanta classification. Blood or tissue samples and baseline clinical characteristics were recorded. The t test and chi-square test were used to evaluate differences between the 2 groups. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curves were used to investigate protective factors. One-way repeated measures analysis of variance was used to evaluate the prognosis of SAP patients.
RESULTS
In our study, compared with APACHII score (AUC 0.829 [95% CIs 0.769-0.889]) and Ranson score (AUC 0.629 [95% CIs 0.542-0.715]), our predictive model (AUC 0.918 [95% CIs 0.875-0.961]) showed better prognostic performance in predicting poor patient outcomes. In the SAP group, changes in fT3 level were significantly associated with prognosis (P<0.05).
CONCLUSIONS
The predictive model can improve the diagnostic accuracy and prediction of the severity of disease. FT3 level could be used as an independent risk factor to predict the mortality of SAP patients.

Keywords: 3'-bromo-3,5,5'-triiodothyronine; Interleukin-10; Interleukin-6; Pancreatitis

Editorial

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Dinah V. Parums
Scientific Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935624

Med Sci Monit 2021; 27:e935624

SARS-CoV-2/COVID-19

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Med Sci Monit In Press; DOI: 10.12659/MSM.934102  

01 December 2021 : Editorial  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750