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02 August 2021 : Clinical Research

[In Press] Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children

Danni He12BCDEF, Xiuxiu Lu3ABCDEFG, Wei Li3BG, Yuanyuan Wang4BD, Ning Li3BC, Yuanmei Chen2CEG, Lipeng Zhang25EF, Wenquan Niu1AEF, Qi Zhang2AEG

DOI: 10.12659/MSM.932518

Med Sci Monit In Press; DOI: 10.12659/MSM.932518  

Available online: 2021-08-02, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
We designed an association study among 267 cases of children with sepsis and 283 healthy controls, by genotyping 9 variants in the VDR gene.
MATERIAL AND METHODS
This was a hospital-based, case-control, genetic association study. In addition to 3 genetic modes of inheritance, haplotype and interaction analyses were employed to examine the prediction of VDR gene for pediatric sepsis. Effect-size estimates are expressed as odds ratio (OR) and 95% confidence interval (CI).
RESULTS
Two variants in the VDR gene, rs2107301 and rs2189480, were found to play a leading role in susceptibility to sepsis in children. The mutant homozygotes of rs2107301 (CC) and rs2189480 (CC) were associated with a reduced risk of sepsis compared with the corresponding wild homozygotes (OR: 0.44 and 0.43, 95% CI: 0.21-0.92 and 0.23-0.81, p: 0.03 and 0.009, respectively). The mutations of rs2107301-C and rs2189480-C alleles were associated with reduced sepsis risk. Haplotype C-C-C-C-C-T-C-A-G in the VDR gene was significantly associated with a 0.59-fold decreased risk of sepsis (95% CI: 0.12-0.76, p: 0.02). In the haplotype–phenotype analysis, significant association was noted for high-density lipoprotein, even after simulation correction (psim <0.05).
CONCLUSIONS
Taken together, our findings indicate that the VDR gene may be a sepsis-susceptibility gene in Chinese Han children.

Keywords: Adult Children; Risk Assessment; Sepsis; MED4 Protein, Human

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Medical Science Monitor eISSN: 1643-3750