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Medical Science Monitor Basic Research


eISSN: 1643-3750

Association of Lymphocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke

Lining Chong, Lin Han, Ruqian Liu, Guomei Ma, Hao Ren

Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, China (mainland)

Med Sci Monit 2021; 27:e930076

DOI: 10.12659/MSM.930076

Available online: 2021-03-01

Published: 2021-05-22


BACKGROUND: Poststroke depression (PSD) is a common neuropsychiatric disorder after stroke. The neuroinflammatory response exerts a vital effect in the development of PSD. Lymphocyte-to-monocyte ratio (LMR), a systemic inflammation biomarker, is associated with poor prognosis of acute ischemic stroke (AIS). The purpose of this study was to determine the association between LMR and PSD at 3 months.
MATERIAL AND METHODS: AIS patients (507) were included in this study. Patients were categorized into 3 tertiles and each tertile contains 169 patients: tertile1 (>4.85), tertile 2 (2.96 to 4.85), and tertile 3 (<2.96), based on LMR values and the numbers of patients. PSD was diagnosed with a 17-item Hamilton Depression Scale score of 8 or higher.
RESULTS: Patients (141; 27.8%) were diagnosed with PSD at 3-month follow-up. Patients in the PSD group presented with more severe stroke and lower LMR values (P<0.001). Decreased LMRs were independently associated with occurrence of PSD (middle tertile: odds ratio [OR] 1.823, P=0.037; lowest tertile: OR 3.024, P<0.001). A significant association of a lower LMR value with PSD severity was found (middle tertile: OR 1.883, P=0.031; lowest tertile: OR 2.633, P=0.001). The receiver operating characteristic curve indicates that the optimal threshold of LMR as a predictor for PSD was 3.14, which yielded a sensitivity of 72.4% and a specificity of 68.1%.
CONCLUSIONS: Decreased LMR is independently associated with PSD and increased PSD severity.

Keywords: Depression, Lymphocyte Count, Monocytes, Stroke