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Medical Science Monitor Basic Research


eISSN: 1643-3750

Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study

Yan-Ming Hao, Da-Wei He, Yan Gao, Ling-Na Fang, Pan-Pan Zhang, Ke Lu, Rong-Zhu Lu, Chong Li

Department of Joint Surgery, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China (mainland)

Med Sci Monit 2021; 27:e929389

DOI: 10.12659/MSM.929389

Available online: 2021-01-14

Published: 2021-03-14


BACKGROUND: Accumulated evidence has suggested that hydrogen sulfide (H₂S) has a role in bone formation and bone tissue regeneration. However, it is unknown whether the H₂S content is associated with bone mineral density (BMD) in patients with osteopenia/osteoporosis.
MATERIAL AND METHODS: In the present study, we aimed to explore the changes of serum H₂S in osteopenia and osteoporosis patients. We analyzed femur expression of cystathionine ß synthase (CBS), cystathionine γ lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), which are key enzymes for generating H₂S.
RESULTS: Sixteen (16%) patients had osteopenia, 9 (9%) had osteoporosis, and 75 (75%) had normal BMD. In comparison with patients with normal BMD (controls), the serum levels of H₂S were unexpectedly increased in patients with osteopenia and osteoporosis. This increase was much higher in patients with osteoporosis than in those with osteopenia. Serum H₂S levels were negatively correlated with femoral BMD, but not lumbar BMD. Interestingly, the expression of CBS and CSE were downregulated in femur tissues in patients with osteoporosis, whereas the expression of 3-MST remained unchanged. Serum phosphorus levels, alkaline phosphatase, hemoglobin, and triglycerides were found to be closely associated with CBS and CSE scores in femur tissues.
CONCLUSIONS: Serum H₂S levels and femur CBS and CSE expression may be involved in osteoporosis pathogenesis.

Keywords: Alkaline Phosphatase, Bone Diseases, Metabolic, Hydrogen Sulfide, Osteoporosis