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Medical Science Monitor Basic Research


eISSN: 1643-3750

Different Doses of Oxycodone for Endoscopic Injection Sclerotherapy of Esophageal Varices

Jie Yao, ChunXiao Song, Chen Zhou, HaiLi He, ZheFeng Quan

Department of Anesthesiology, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China (mainland)

Med Sci Monit 2021; 27:e929111

DOI: 10.12659/MSM.929111

Chinese Clinical Trial Registry # ChiCTR-IPR-16010124

Available online: 2021-01-15

Published: 2021-03-17


BACKGROUND: The aim of the present study was to evaluate the effects of different doses of oxycodone during endoscopic injection sclerotherapy (EIS) for esophageal varices with painless sclerosing agents.
MATERIAL AND METHODS: A total of 119 patients were randomly divided into 3 groups: Group A, midazolam and 0.075 mg/kg oxycodone (n=40); Group B, midazolam and 0.1 mg/kg oxycodone (n=40); and Group C, midazolam and 0.125 mg/kg oxycodone (n=39). The main observation index was the incidence of body movement during the perioperative period. The secondary indices were additional propofol usage; postoperative analgesic usage; other adverse effects, such as hypoxia, myoclonus, and cough; and satisfaction scores for surgeons and patients.
RESULTS: The incidence rates for body movement during the perioperative period in groups A, B, and C were 33%, 13%, and 0, respectively (P<0.001). The satisfaction scores for surgeons and patients were highest in Group C (0.125 mg/kg oxycodone). The incidence rates for hypoxia before EIS were 15%, 8%, and 33% (P=0.026) and during EIS were 23%, 3%, and 0% (P<0.001), respectively. There were no significant between-group differences with respect to other adverse effects.
CONCLUSIONS: The ideal dose of oxycodone for perioperative analgesia during EIS for esophageal varices is 0.125 mg/kg.

Keywords: Endoscopy, Digestive System, Oxycodone, Personal Satisfaction