Correlation Between Speech Repetition Function and the Arcuate Fasciculus in the Dominant Hemisphere Detected by Diffusion Tensor Imaging Tractography in Stroke Patients with Aphasia
Hong Wang, Shuqing Li, Yanhong Dai, Qiwei Yu
Department of Rehabilitation Medicine, The First Afﬁliated Hospital of Jinan University, Guangzhou, Guangdong, China (mainland)
Med Sci Monit 2020; 26:e928702
Available online: 2020-11-24
Repetition disorder can be used as an important criterion for aphasia classification, and damaged arcuate fasciculus in the dominate hemisphere has been reported to be closely related to repetition disorder, but the underlying neurological mechanism remains unclear.
MATERIAL AND METHODS: Fifteen stroke patients with poststroke aphasia and 9 healthy controls were included in the study. The value of fractional anisotropy (FA) in the dominate arcuate fasciculus in stroke patients and healthy controls were measured using DTI. We also assessed their repetition dysfunction with the Aphasia Battery of Chinese (ABC) assessment and calculated the correlation between the FA values in the dominate arcuate fasciculus and ABC scores of word repetition and sentence repetition.
RESULTS: There was a moderate correlation between the total score of repetition evaluation and the FA value of injured arcuate fasciculus in the dominant hemisphere (r=0.551, P=0.033). We found no correlation between the score of word repetition and the FA value of injured arcuate fasciculus in the dominant hemisphere (r=0.330, P=0.230), but there was a strong correlation between the score of sentence repetition and the FA value of injured arcuate fasciculus in the dominant hemisphere (r=0.795, P≤0.001).
CONCLUSIONS: We found that unintegrated left arcuate fasciculus might be related to the repetition dysfunction after stroke, especially sentence repetition deficit, which suggests that sentence repetition evaluation could be used to indicate the integrity of the arcuate fasciculus in the dominant hemisphere after stroke.
Keywords: Aphasia, diffusion tensor imaging, Stroke