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Medical Science Monitor Basic Research


eISSN: 1643-3750

Connection Between CDC20 Expression and Hepatocellular Carcinoma Prognosis

Xianfeng Zhang, Xianjun Zhang, Xinguo Li, Hongbing Bao, Guang Li, Ning Li, Hengli Li, Jian Dou

Department of Hepatopancreatobiliary Surgery, Harrison International Peace Hospital, Hengshui, Hebei, China (mainland)

Med Sci Monit 2021; 27:e926760

DOI: 10.12659/MSM.926760

Available online: 2021-02-04

Published: 2021-03-31


BACKGROUND: Hepatocellular carcinoma (HCC) occurs frequently in China, with high morbidity and mortality. Cell division cycle 20 homolog (CDC20) is reportedly related to many cancers. In this study, we discuss a potential link of CDC20 expression to HCC patients’ prognoses.
MATERIAL AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess CDC20 expression in HCC and the paired noncancerous tissues. Chi-square analysis was used to assess potential association of CDC20 expression with clinicopathologic profiles among HCC patients. The overall survival for HCC patients with different CDC20 expressions was assessed using the Kaplan-Meier method. To evaluate the prognostic value for HCC patients, Cox regression analyses were performed.
RESULTS: The expression of CDC20 was elevated among HCC specimens compared with adjacent noncancerous ones (P<0.05). The expression of CDC20 was significantly related to differentiation (P<0.001), tumor node metastasis stage (P<0.001), and lymphatic metastasis (P<0.001). Moreover, HCC patients with high CDC20 expression had dismal overall survival rates compared with low CDC20 expression (P<0.05). CDC20 alone could forecast HCC prognoses according to multivariable Cox regression analysis (hazard ratio=2.354, 95% confidence interval=1.177-4.709, P=0.016).
CONCLUSIONS: Overexpressed CDC20 may act as a reliable biomarker for dismal prognoses among HCC patients.

Keywords: Carcinoma, Hepatocellular, Cdc20 Proteins, Prognosis