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23 December 2020 : Clinical Research

A Real-World Study of Cerebral 99mTc-TRODAT-1 Single-Photon Emission Computed Tomography (SPECT) Imaging of the Dopamine Transporter in Patients with Parkinson Disease from a Tertiary Hospital in Brazil

Michelly Arjona1CDEF, Juliana M.P. Toldo1BCDEF, Natalia Carvalho Queiroz1ABCD, Jose Luiz Pedroso2ACD, Guilherme de Carvalho Campos Neto2ACD, Orlando G.P. Barsottini2ACD, Andre C. Felicio1ABCDEF*

DOI: 10.12659/MSM.925130

Med Sci Monit 2020; 26:e925130

Abstract

BACKGROUND: Studies on the routine clinical use of dopamine transporter (DAT) imaging have largely been conducted in Europe and the United States. In this real-world study, we investigated the use of cerebral 99mTc-TRODAT-1 SPECT imaging of DAT in patients with Parkinson disease (PD) at a tertiary hospital in Brazil.

MATERIAL AND METHODS: We included 119 patients with suspected PD or clinically unclear parkinsonism who underwent brain scintigraphy with 99mTc-TRODAT-1 during a 3-year period. Additionally, a brief interview was conducted with the physician who requested the scan to determine the usefulness of the method in clinical decision-making.

RESULTS: Regarding the scan requests, most were intended to evaluate or confirm dopaminergic denervation (69%), distinguish PD from essential tremor (10%), or distinguish degenerative parkinsonism from drug-induced parkinsonism (6%). Data analysis showed that scintigraphy with 99mTc-TRODAT-1 was useful in 85% of cases, changing the management of 75% of the patients who underwent a scan. The majority of physicians who requested the scan were neurologists, and 54% were self-reported movement disorder specialists. An inappropriate use of DAT imaging was seen in 5% of cases.

CONCLUSIONS: This study demonstrated that brain scintigraphy with the DAT ligand 99mTc-TRODAT-1 may influence diagnostic or therapeutic interventions, meaning that Brazilian physicians who requested the exam have taken in vivo DAT results into account at the time of clinical decision-making.

Keywords: Brain Mapping, perfusion imaging

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750