Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 1643-3750

The Relationship Between Corneal Hysteresis and Retinal Ganglion Cells – A Step Forward in Early Glaucoma Diagnosis

Vasile Potop, Valeria Coviltir, Speranţa Schmitzer, Catalina Corbu, Ioana Cătălina Ionescu, Miruna Burcel, Dana Dăscălescu

Departament of Ophthalmology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Med Sci Monit 2020; 26:e924672

DOI: 10.12659/MSM.924672

Available online: 2020-06-23

Published: 2020-08-25


BACKGROUND: Glaucoma is a major cause of irreversible visual field (VF) loss across the world. Many studies have assessed the accuracy of glaucoma diagnostic tests for a more precise diagnosis to quickly identify patients with higher risk of progression.
MATERIAL AND METHODS: We conducted a study that included 214 eyes divided into 3 groups: 79 eyes from patients diagnosed with primary open-angle glaucoma (POAG), 68 eyes from patients diagnosed with ocular hypertension (OH), and 67 eyes from normal individuals (normal eyes, NE). All patients included in the study received a complete checkup.

RESULTS: In POAG patients, means of central corneal thickness (CCT), corneal hysteresis (CH), corneal resistance factor (CRF), mean defect (MD), visual field index (VFI), peripapillary retinal nerve fiber layer (pRNFL), and ganglion cell complex (GCC) are lower than in OH patients, and in NE are higher than in both groups. Also, we found a statistically significant direct correlation between CH and GCC thickness. Further statistical analysis revealed that both pRNFL thickness and GCC thickness are significantly influenced by CH value in a precise manner.
CONCLUSIONS: The first cell type affected in glaucoma is the retinal ganglion cell. We found a positive correlation between GCC thickness and CH, suggesting that CH might be a parameter to consider in the evaluation of all glaucoma patients from their first examination. Moreover, both pRNFL thickness and GCC thickness are influenced by CH, suggesting the utility of monitoring the value of CH at every checkup to detect its decrease in glaucoma patients.

Keywords: Corneal Pachymetry, Glaucoma, Open-Angle, Ocular Hypertension, Retinal Ganglion Cells