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29 August 2020 : Database Analysis  

Efficacy of Primary Tumor Resection in Metastatic Colorectal Cancer

Yong Huang1BCEF, Kuanxue Ge2BCD, Guangshun Fu1F, Junfeng Chu3AB, Wei Wei1AE*

DOI: 10.12659/MSM.923501

Med Sci Monit 2020; 26:e923501

Abstract

BACKGROUND: The aim of this study was to evaluate the survival benefit of palliative primary tumor resection in colorectal cancer (CRC) patients with unresectable metastases.

MATERIAL AND METHODS: Clinicopathological characteristics of eligible patients who underwent surgery to remove the primary tumor and those who did not between 2004 and 2013 were compared. We also evaluated the association between survival and different clinicopathologic characteristics in metastatic CRC.

RESULTS: The percentage of patients undergoing surgical resection of the primary tumor was higher during the earlier years and trended toward less use of surgery in later years. Palliative primary tumor resection was strongly associated with better cause-specific survival (hazard ratio=0.403, 95% confidence interval=0.389 to 0.417, P<0.001).

CONCLUSIONS: We added new strong evidence supporting the survival benefit of palliative resection, which should be confirmed in future randomized controlled trials.

Keywords: Colorectal Neoplasms, Neoplasm Metastasis, Neoplasms, Unknown Primary, Palliative Care

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Editorial

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Dinah V. Parums
Scientific Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935624

Med Sci Monit 2021; 27:e935624

SARS-CoV-2/COVID-19

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01 December 2021 : Editorial  

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Med Sci Monit 2021; 27:e935624

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750