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Medical Science Monitor Basic Research


eISSN: 1643-3750

Serum Cytokines and FeNO in School-Aged Children with Mycoplasma pneumoniae Pneumonia

Hai-li Jin, Lu Zhan, Shu-fen Mei, Zheng-yang Shao

Department of Pediatrics, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou, Zhejiang, China (mainland)

Med Sci Monit 2020; 26:e923449

DOI: 10.12659/MSM.923449

Available online: 2020-04-23

Published: 2020-06-21


BACKGROUND: Mycoplasma pneumoniae is a major cause of community-acquired pneumonia (CAP) that is particularly prevalent in school-aged children. This study explored the potential involvement of cytokines in children with Mycoplasma pneumoniae pneumonia (MPP) infection.
MATERIAL AND METHODS: Children aged 3-7 years who were hospitalized due to CAP infection were enrolled and divided into 2 groups: an MPP group (n=33) and a NMPP group (n=38), along with 21 age-matched healthy controls. Clinical characteristics and laboratory data were recorded. Serum levels of IL-18, IL-33, IFN-γ, IL-5, IL-6, IL-8, and IL-13 were assessed using Luminex xMAP technology. Correlation analysis and ROC curves analysis were also performed to further explore the role of these detected cytokines in CAP.
RESULTS: Compared with the healthy controls, the serum expression of IL-18, IL-33, IFN-γ, IL-5, IL-6, IL-8, and IL-13 were significantly higher in the MPP and NMPP groups. Furthermore, serum IL-18 expression was found to be significantly correlated with lgE, FeNO, IL-5, IL-8, and IL-13 concentrations. Significant differences were also observed between the MPP group and NMPP group patients in levels of IL-18, IL-5, and IL-6, and further ROC analysis showed that the area under the curve (AUC) of IL-18 and IL-5 were 0.813 (95% CI: 0.710-0.917; P<0.01) and 0.844 (95% CI: 0.756-0.933; P<0.01), respectively.
CONCLUSIONS: IL-18, IL-33, IFN-γ, IL-5, IL-6, IL-8, and IL-13 serum levels showed significant differences in children with CAP. IL-18 and IL-5 were much higher in the MPP group compared to the NMPP group patients, whereas IL-6 levels were significantly lower in these 2 groups.

Keywords: Cytokines, Luminescent Measurements, Nitric Oxide, Pneumonia, Pneumonia, Mycoplasma, Receptors, Interleukin-18