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eISSN: 1643-3750

Circular RNA (circRNA) CDYL Induces Myocardial Regeneration by ceRNA After Myocardial Infarction

Min Zhang, Zhen Wang, Qiushi Cheng, Zhihong Wang, Xiaobing Lv, Zhong Wang, Na Li

Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland)

Med Sci Monit 2020; 26:e923188

DOI: 10.12659/MSM.923188

Available online: 2020-04-14

Published: 2020-06-11

BACKGROUND: The aim of the study was to assess the effect of circRNA CDYL on myocardial angiogenesis after acute myocardial infarction (AMI).
MATERIAL AND METHODS: We compared changes in circRNA CDYL and myocardial angiogenesis in myocardial infarction tissue and normal heart tissue by establishing a myocardial infarction mouse model to clarify the relationship between circRNA CDYL and changes in myocardial infarction and myocardial angiogenesis. Secondly, we used the RegRNA website to predict downstream miRNA, and we performed gain-of-function and loss-of-function experiments.
RESULTS: CircCDYL was downregulated in myocardial tissues and hypoxia myocardial cells, and overexpression and downregulation of circCDYL improved and aggravated, respectively, heart function after AMI. CircCDYL overexpression and downregulation can promote and inhibit, respectively, proliferation of cardiomyocytes in vitro. Finally, we found that circCDYL can sponge miR-4793-5p and regulate its expression, and then miR-4793-5p regulates APP expression.
CONCLUSIONS: CircCDYL can promote the proliferation of cardiomyocytes through the miR-4793-5p/APP pathway.

Keywords: MicroRNAs, Myocardial Infarction, Regeneration