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06 June 2020 : Laboratory Research  

Antimicrobial Activity of Nano-Magnesium Hydroxide Against Oral Bacteria and Application in Root Canal Sealer

Yingying Meng12ABCDEF, Dan Zhang12ADF, Xingya Jia12AEF, Keshen Xiao3AC, Xiao Lin4DE, Yi Yang5AF, Dake Xu5DE, Qiang Wang12G*

DOI: 10.12659/MSM.922920

Med Sci Monit 2020; 26:e922920

Abstract

BACKGROUND: The goal of the present work was to assess the antibacterial activity of nano-magnesium hydroxide (NMH) against Streptococcus mutans (S. mutans) and to explore the antimicrobial function of AH Plus™ sealer incorporating NMH.

MATERIAL AND METHODS: The antimicrobial behavior of NMH against S. mutans was evaluated with bactericidal tests. A modified direct contact test was used to assess the antimicrobial activity of unset AH Plus containing NMH after 5 minutes, 20 minutes, and 60 minutes of contact with bacteria. The antimicrobial effects and the amount of surface-adhering bacteria of the solidified materials were explored by SEM and confocal laser scanning microscopy, respectively.

RESULTS: NMH powder presented excellent antimicrobial activity against S. mutans. Mg²⁺ and OH⁻ were not the main factors resulting in bacterial death. Approximately 93.1% and 98% of the S. mutans were killed in the AH Plus+7% NMH group after incubation for 5 minutes and 20 minutes, respectively. AH Plus with 5% or 7% NMH were more potent against S. mutans compared with AH Plus alone (P<0.05). Moreover, the antibacterial function of AH Plus was lost after setting. NMH enabled the solidified AH Plus to still have antibacterial properties on the seventh day.

CONCLUSIONS: NMH can be used to modify AH Plus sealer to eradicate residual bacteria and prevent reinfection.

Keywords: Magnesium Hydroxide, Root Canal Therapy, Streptococcus mutans

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750