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31 May 2020 : Clinical Research  

An Individualized Immune Prognostic Index is a Superior Predictor of Survival of Hepatocellular Carcinoma

Xiaodong Wang1BCDEF, Yuquan Wu1BCD, Dongyue Wen1ACDE, Lin-yong Wu1BCD, Yujia Zhao1BCE, Yun He1ACEF, Hong Yang1ACDEFG*

DOI: 10.12659/MSM.921786

Med Sci Monit 2020; 26:e921786


BACKGROUND: The tumor microenvironment is largely orchestrated by the immune cells. Considerable evidence has shown their excellent clinicopathological application value in assessment of clinical outcomes and immunotherapy efficacy. Hence, a moderate, individualized prognostic signature based on immune cells that can estimate prognosis and reflect the immune microenvironment in hepatocellular carcinoma (HCC) patients is greatly needed.

MATERIAL AND METHODS: Here, we systematically analyzed the expression differences and survival prediction value of tumor infiltrating immune cells by analyzing 638 HCC patients from 3 public cohorts, including 2 microarray datasets and 1 RNA sequencing dataset. CIBERSORT software, a computational algorithm, was used to calculate the relative levels of immune cells. Three immune microenvironment subtypes were defined via ConsensuClusterPlus package. Univariate and multivariate survival analyses were used to develop an individualized immune prognostic index based on immune cell pairs.

RESULTS: Notably, HCC patients with higher immune signatures score, utterly appreciable, suffered inferior prognosis (hazard ratio=2.742; 95% confidence interval: 1.887–3.983; P<0.001). Subgroup analysis suggested that the prognostic signature did particularly well in early-stage patients. Furthermore, moderate survival prediction value was also confirmed in another two independent cohorts GSE14520 and GSE76427.

CONCLUSIONS: This study provides a systematic view of the immune cells characteristics in HCC and suggests their superior survival monitoring performance.

Keywords: Allergy and Immunology, Carcinoma, Hepatocellular, Cellular Microenvironment, Prognosis, B-Lymphocyte Subsets, B-Lymphocytes, Cluster Analysis, Cohort Studies, Databases, Factual, Dendritic Cells, Eosinophils, Immune System, Killer Cells, Natural, Liver Neoplasms, Lymphocytes, Tumor-Infiltrating, Macrophages, Mast Cells, Monocytes, Multivariate Analysis, Neutrophils, Plasma Cells, Survival Rate, T-Lymphocyte Subsets, T-Lymphocytes, tumor microenvironment



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Editorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937048

Med Sci Monit 2022; 28:e937048


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750