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11 February 2020 : Clinical Research  

Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control

Deniz Gül1ABCD, Aydan Orsçelik2ABEF*, Serkan Akpancar1ABCDEF

DOI: 10.12659/MSM.919166

Med Sci Monit 2020; 26:e919166

Abstract

BACKGROUND: Osteoarthritis secondary to developmental dysplasia of the hip (DDH) is one of the major causes of hip pain and disability. The aim of the study was to compare the effectiveness of prolotherapy (PrT) injections versus exercise protocol for the treatment of DDH.

MATERIAL AND METHODS: There were 46 hips of 41 patients who had osteoarthritis secondary to DDH included in this study. Patients were divided into 2 groups: treated with PrT (PrT group; n=20) and exercise (control group; n=21). Clinical outcomes were evaluated with visual analog scale for pain (VAS) and Harris hip score (HHS) at baseline, 3 weeks, 3 months, 6 months, and a minimum of 1-year follow-up. In PrT group clinical results were also compared in Crowe type I–IV hips.

RESULTS: Between group analysis revealed no significant between group differences at baseline. Dextrose injection recipients out performed exercise controls for VAS pain change score at 6 months (–4.6±2.6 versus –2.8±2.5; P=0.016), and 12 months (–4.5±2.4 versus –2.9±2.5; P=0.017) and for HHS at 6 months (24.2±14.0 versus 14.8±12.4; P=0.007) and 12 months (24.3±13.4 versus 16.5±11.3; P=0.018).

CONCLUSIONS: To our best knowledge, this study is the first regarding the effects of an injection method in the treatment of osteoarthritis secondary to DDH. According to our study, PrT is superior to exercises. PrT could provide significant improvement for clinical outcomes in DDH and might delay surgery.

Keywords: Hip Dislocation, Congenital, Hip Joint, Injections, Osteoarthritis, Hip, regenerative medicine, Treatment Outcome, Adolescent, Adult, Aged, Aged, 80 and over, Arthralgia, Follow-Up Studies, Glucose, Middle Aged, Osteoarthritis, Pain Measurement, Prolotherapy, resistance training, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750