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20 December 2019 : Clinical Research

A New Application of Multimodality Radiomics Improves Diagnostic Accuracy of Nonpalpable Breast Lesions in Patients with Microcalcifications-Only in Mammography

Shujun Chen123AG, Xiaojun Guan4D, Zhenyu Shu5C, Yongfeng Li167B, Wenming Cao189B, Fei Dong4F, Minming Zhang4A, Guoliang Shao123G, Feng Shao11011F*

DOI: 10.12659/MSM.918721

Med Sci Monit 2019; 25:9786-9793

Abstract

BACKGROUND: The aim of this study was to assess a radiomic scheme that combines image features from digital mammography and dynamic contrast-enhanced MRI to improve classification accuracy of nonpalpable breast lesion (NBL) with Breast Imaging-Reporting and Data System (BI-RADS) 3-5 microcalcifications-only in mammography.

MATERIAL AND METHODS: This retrospective study was approved by the Internal Research Review and Ethical Committee of our hospital. We included 81 patients who underwent a three-dimensional digital breast X-ray wire positioning for local resection between October 2012 and November 2016. All patients underwent breast MRI and mammography before the treatment, and all obtained pathological confirmation. According to the pathological results, 41 patients with benign lesions were assigned to the benign group and 40 patients with malignant lesions were assigned to the malignant group. We used the random forest algorithm to select significant features and to test the single and multimodal classifiers using the Leave-One-Out-Cross-Validation method. An area under the receiver operating characteristic curve was also used to evaluate its discriminating performance.

RESULTS: The multimodal classifier achieved AUC of 0.903, with a sensitivity of 82.5% and a specificity of 80.48%, which was better than any single modality.

CONCLUSIONS: Multimodal radiomics classification shows promising power in discriminating malignant lesions from benign lesions in NBL patients with BI-RADS 3-5 microcalcifications-only in mammography.

Keywords: Diagnosis, Mammography

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750