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20 January 2020 : Clinical Research  

Expression of MiR-140 and MiR-199 in Synovia and its Correlation with the Progression of Knee Osteoarthritis

Yu Chao1ABEF, Liwen Zhang1EF, Xiang Zhang1CD, Cong Ma2BG, Zhijun Chen1ABC*

DOI: 10.12659/MSM.918174

Med Sci Monit 2020; 26:e918174

Abstract

BACKGROUND: The aim of this study was to explore the expression of miR-140 and miR-199 in synovia of patients with knee osteoarthritis (KOA) and its correlation with the progression of this disease. We used the Kellgren and Lawrence grading (KLG) system.

MATERIAL AND METHODS: There were 110 patients with early (KLG <2), middle (KLG=2) and late (KLG >2) stage KOA and 60 healthy individuals (control) included in this study.

RESULTS: The relative expression levels of miR-140 (1.07±0.091) and miR-199 (1.03±0.110) in synovia of the control group were higher than those of KOA groups (0.511±0.130, 0.298±0.168) and the difference exhibited statistical significance (P<0.01). Expression of miR-140 in the middle and the late stage KOA groups (0.322±0.118 and 0.110±0.088 respectively) were 58.80% and 81.29% lower, respectively, compared to the early stage KOA group (0.588±0.172), which was significant (P<0.05). Expression of miR-199 in the middle and the late stage KOA groups (0.210±0.124 and 0.056±0.068 respectively) were 39.41% (P<0.05) and 83.72% (P<0.01) respectively lower than that in the early KOA group (0.344±0.147). The severity of OA was significantly negatively correlated with the expressions of miR-140 and miR-199 (r=–0.859, P<0.05; r=–0.724, P<0.001 respectively). Matrix metalloproteinase (MMP)-3 levels of the early stage, middle stage and late stage KOA groups were 1.320±0.118, 1.488±0.210, and 1.955±0.023 respectively; and IL-1β mRNA was 1.401±0.204, 1.522±0.210, and 1.889±0.217 respectively, which were obviously higher than those in the control group (1.020±0.085), (P<0.05).

CONCLUSIONS: Expression levels of miR-140 and miR-199 in synovia might act as an early diagnostic marker for KOA. These expression levels might also act as indicators of OA progression to some extent.

Keywords: Osteoarthritis, Hip, Osteoarthritis, Knee, Osteoarthritis, Spine, Case-Control Studies, Disease Progression, Gene Expression Regulation, Matrix Metalloproteinase 3, MicroRNAs, Synovial Membrane

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750