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30 December 2019 : Clinical Research

MicroRNA-204 as an Indicator of Severity of Pulmonary Hypertension in Children with Congenital Heart Disease Complicated with Pulmonary Hypertension

Xu Li1ACEG, Daokang Xiang1ACEG*, Yizhu Shu1BD, Kui Hu1CE, Yongchun Zhang1EF, Yonghong Li1AC

DOI: 10.12659/MSM.917662

Med Sci Monit 2019; 25:10173-10179

Abstract

BACKGROUND: The objective of this study was to investigate the changes and significance of microRNA-204 (miR-204) in children with congenital heart disease (CHD) complicated with pulmonary hypertension (PH).

MATERIAL AND METHODS: Fifty-two CHD patients with left-to-right shunt were divided into 3 groups according to preoperative pulmonary artery systolic pressure (PASP) detected by color Doppler echocardiography: a control group (PASP <30 mmHg), a mild PH group (PASP 30–49 mmHg), and a severe PH group (PASP >50 mmHg). Peripheral venous blood and supernatant were collected on an empty stomach at 1 h before surgery and 7 days after surgery. The expression of miR-204 in plasma was detected by RT-qPCR.

RESULTS: One hour before surgery and 7 days after surgery, plasma miR-204 expression was at a higher level than that in the mild PH group and higher than in the severe PH group. miR-204 expression in children in each group showed a decreasing trend after surgery. The mild PH and severe PH groups had lower plasma miR-204 expression and PASP after surgery than before surgery. In the mild PH and severe PH groups, plasma miR-204 expression was negatively correlated with PASP. In all 52 cases, plasma miR-204 expression was negatively correlated with PASP.

CONCLUSIONS: The plasma miR-204 expression in CHD children with PH was negatively correlated with the degree of PH, suggesting miR-204 may be involved in PH development, and miR-204 expression may be an indicator of PH severity.

Keywords: Heart Defects, Congenital, Pulmonary Heart Disease, Severity of Illness Index

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750