24 June 2019 : Clinical Research
Control of Anticoagulation Therapy in Patients with Atrial Fibrillation Treated with Warfarin: A Study from the Chinese Atrial Fibrillation Registry
Hai-Feng Liang12ABCDEF, Xin Du1ADEF, Ying-Chun Zhou3CD, Xiao-Yi Yang3BC, Shi-Jun Xia1BF, Jian-Zeng Dong1BDF, Gregory Y.H. Lip45ADEF, Chang-Sheng Ma1ABCEFG*DOI: 10.12659/MSM.917131
Med Sci Monit 2019; 25:4691-4698
Abstract
BACKGROUND: Several factors determine the efficacy of warfarin anticoagulation in patients with non-valvular atrial fibrillation (NVAF). This study aimed to use data from the Chinese Atrial Fibrillation Registry study to assess the control of anticoagulation therapy in Chinese patients with NVAF treated with warfarin.
MATERIAL AND METHODS: From the Chinese Atrial Fibrillation Registry study the anticoagulant use and dosing, the time in therapeutic range (TTR) of the international normalized ratio (INR), and standard deviation of the observed INR values (SDINR), and their influencing factors were evaluated.
RESULTS: The median INR and SDINR were 2.04 (IQR 1.71–2.41) and 0.50 (IQR, 0.35–0.69), respectively. The median TTR was 51.7% (IQR, 30.6–70.1%) and only 25.1% had a TTR ≥70%. Age was ≥70 years (OR, 0.72; 95% CI, 0.55–0.94; P=0.015), bleeding history (OR 0.48; 95% CI, 0.23–0.89; P=0.029), the use of a single drug (OR, 0.62; 95% CI, 0.42–0.92; P=0.016), more than drug (OR, 0.60; 95% CI, 0.41–0.88; P=0.009), and lack of assessment of bleeding risk (OR, 0.72; 95% CI, 0.54–0.97; P=0.033) were associated with TTR <70% (INR 2.0–3.0). Coronary heart disease (CHD) and peripheral artery disease (PAD) (OR, 0.69; 95% CI, 0.52–0.90; P=0.007) and diabetes mellitus (OR, 0.79; 95% CI, 0.62–0.99; P=0.044) were associated with increased variability in INR (SDINR ≥0.5).
CONCLUSIONS: In Chinese patients with NVAF, warfarin anticoagulation was associated with lower TTR and less stable anticoagulation than in current guidelines, and risk factors for reduced safety and efficacy were identified.
Keywords: Anticoagulants, Atrial Fibrillation, Quality Control, Warfarin, Aged, 80 and over, Asians, Blood Coagulation, Hemorrhage, International Normalized Ratio, Registries, Risk Factors, Stroke, Thrombolytic Therapy
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