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20 June 2019 : Clinical Research

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Konrad Dziobek1ABE*, Marcin Opławski2ABE, Beniamin Grabarek3CDE, Nikola Zmarzły3DF, Piotr Januszyk4E, Iwona Adwent4D, Dariusz Dąbruś4C, Ewa Leśniak4B, Robert Kiełbasiński5C, Przemysław Kieszkowski6F, Dariusz Boroń147A

DOI: 10.12659/MSM.916762

Med Sci Monit 2019; 25:4569-4574

Abstract

BACKGROUND: SEMA3B is known as an inhibitor of angiogenesis and cell proliferation. During carcinogenesis, the loss of SEMA3B function is observed, which results in the progression of neoplastic changes. The aim of this study was to evaluate the expression profile of SEMA3B in endometrial cancer (G1-G3) in comparison to the control group and to assess whether the observed changes in expression could become a molecular marker in endometrial cancer.

MATERIAL AND METHODS: The study group consisted of 45 patients diagnosed with endometrial cancer (G1, 17; G2, 15; G3, 13). The control group included 15 patients. SEMA3B expression was assessed using the immunohistochemical method. Statistical analysis was carried out using the Statistica 12 PL program (StatSoft, USA). It included the Kruskal-Wallis test and post hoc Dunn’s test (p<0.05).

RESULTS: Statistically significant differences in the level of SEMA3B expression were observed between all analyzed groups. The expression pattern of SEMA3B was as follows: cancer cells G1>G2>G3; endothelial cells: G3>G1>G2; stromal cells: G2>G1>G3.

CONCLUSIONS: Analysis of the SEMA3B expression profile shows the complexity of neoplastic transformation, which confirms the different expression of SEMA3B in endometrial cancer cells and endothelial cells. The present results and data in the literature data suggest that SEMA3B expression indicates the progression of carcinogenesis in the context of endometrial cancer.

Keywords: Angiogenesis Inducing Agents, Endometrial Neoplasms

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750